ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Impact of a predefined mediastinal ROI on inter-observer variability of planar ¹²³I-MIBG heart-to-mediastinum ratio.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Three-Dimensional Heart Segmentation and Absolute Quantitation of CardiacAnnals of nuclear cardiology · 2023Article
- CardiacPharmaceuticals (Basel, Switzerland) · 2022Review
- How to best appreciate the possible clinical role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Observational
- A European myocardialJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Influence of ROI definition on the heart-to-mediastinum ratio in planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Standardization ofClinical and translational imaging · 2017Review
- Cardiac sympathetic activity in chronic heart failure: cardiacNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
aimPurpose of this study was to assess the impact of mediastinal region of interest (ROI) definition on intra- and inter-observer variability in relation to collimator type.
methodsThirty-five subjects with CHF (80% men, mean age 66 ± 9 years, NYHA 2.4 ± 0.5, LVEF 29 ± 8.4%) were enrolled. 15 minutes and 4 hours post-injection (p.i.) of (123)I-MIBG, planar images were sequentially acquired with low energy high energy (LEHR) and medium energy (ME) collimators. In the first analysis, observer-defined mediastinal ROI was used. In the second analysis, a predefined mediastinal ROI was used. Intra- and inter-observer variability of late H/M was assessed using Lin's concordance coefficient (LCC).
resultsThere was substantial agreement between all three observers using predefined mediastinum ROI. LCCs for LEHR were 0.98, 0.96, and 0.95, for ME 0.98, 0.97, and 0.97. However, observer-defined mediastinal ROI resulted in poor-moderate agreement. LCCs for LEHR were 0.82, 0.94, and 0.70, for ME 0.77, 0.91, and 0.80. Intra-observer analysis using predefined mediastinal ROI showed substantial agreement. LCC was 0.97 for LEHR and 0.96 for ME.
conclusionPredefined mediastinal ROI results in low intra- and inter-observer variability of late H/M and is, therefore, to be preferred over observer-defined mediastinal ROI. Intra- and inter-observer variability of late H/M is not influenced by collimator choice.
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