ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Comparative study of the relative signal intensity on DWI, FLAIR, and T2 images in identifying the onset time of stroke in an embolic canine model.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Trial
- Comparative study of image quality, ADC, and IVIM data between multi-b value MUSE-DWI and SS-EPI-DWI in brain imaging.BMC medical imaging · 2025Article
- Hypoxic brain damage in Methadone misuse: insights from MRI imaging and comparative study.Acta neurologica Belgica · 2025Article
- Deep learning-based classification of diffusion-weighted imaging-fluid-attenuated inversion recovery mismatch.Scientific reports · 2025Article
- Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion.Frontiers in neurology · 2024Article
- Suspected spontaneous early hemorrhagic transformation of multiple ischemic strokes secondary to primary splenic torsion in a German Shepherd dog.Journal of veterinary internal medicine · 2022Article
- Temporal and sequence-related variability in diffusion-weighted imaging of presumed cerebrovascular accidents in the dog brain.Frontiers in veterinary science · 2022Article
- Development and Testing of Thrombolytics in Stroke.Journal of stroke · 2021Review
- Imaging Ischemic and Hemorrhagic Disease of the Brain in Dogs.Frontiers in veterinary science · 2020Review
- A Comparison of TJournal of central nervous system disease · 2020Article
- Acute cerebrovascular event in a dog with polycythemia vera.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model.Journal of veterinary science · 2018Article
- Temporal evolution of the signal intensity of hyper-acute ischemic lesions in a canine stroke model: influence of hyperintense acute reperfusion marker.Japanese journal of radiology · 2017Article
- High b value DWI in evaluation of the hyperacute cerebral ischemia at 3T: A comparative study in an embolic canine stroke model.Experimental and therapeutic medicine · 2016Article
- Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model.Diagnostic and interventional radiology (Ankara, Turkey)Article
- Utility of histogram analysis of ADC maps for differentiating orbital tumors.Diagnostic and interventional radiology (Ankara, Turkey)Article
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Authors and funding
8 authors.
Funding
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Abstract
In acute stroke magnetic resonance imaging, many attempts have been made to identify the onset time of ischemic events using the simply quantitative judgment of relative signal intensity (rSI) from various MR images. However, no uniform opinion has been achieved broadly till now. The controversy might derive from the potential patients' selection bias of clinical retrospective study, the discrepant MR parameters, and the various sample sizes among different studies. Thus, we evaluated the temporal change of the relative DWI signal intensity (rDWI), relative ADC value (rADC), relative FLAIR signal intensity (rFLAIR), and relative T2 signal intensity (rT2), and further compare their diagnostic value in identifying the hyperacute lesions based on our embolic canine model with clear onset time. Twenty ischemic models were successfully established. All rSI values were linearly correlated to time with significance until 24 h after model establishment (P < 0.05). Paired comparison of ROC curves showed that significant difference was found between rADC and other three rSIs (P < 0.0001). However, no significant difference was found among rDWI, rT2 and rFLAIR. Our results indicated that rDWI, rFLAIR and rT2 may be helpful to predict the onset time of ischemic events with the similar diagnostic value. However, the rADC does not have comparable predictive value in our embolic canine model.
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