ArticleThe bone & joint journal2014
The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: a retrospective study.
Article in The bone & joint journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 7 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Population characteristics, glucocorticoid dosage, and risk factors for osteonecrosis of the femoral head in systemic lupus erythematosus: a Systematic Review and meta-analysis.Frontiers in immunology · 2026Pooled it
- The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19.Journal of orthopaedic surgery and research · 2024Pooled it
- Femoral head avascular necrosis in COVID-19 survivors: a systematic review.Rheumatology international · 2023Pooled it
- [Update of the German S3 guideline on atraumatic femoral head necrosis in adults].Der Orthopade · 2018Guideline
- Association of TNF-α-308(G/A) and -238(G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: a meta-analysis.International orthopaedics · 2018Pooled it
- Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations: a dose-response meta-analysis of case-control studies.Clinical rheumatology · 2017Pooled it
- Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Prevalence of Osteonecrosis of the Femoral Head in High-Risk Male Patients with Severe COVID-19 Treated with High-Dose Corticosteroids: A Prospective Cohort Study Using Screening MRI-How Many Have Been Left Behind?Diagnostics (Basel, Switzerland) · 2026Article
- Dexras1 plays a crucial role in glucocorticoid-induced osteonecrosis of the femoral head by mediating imbalance between osteogenesis and adipogenesis.Cellular and molecular life sciences : CMLS · 2026Article
- Characteristics of osteonecrosis of the femoral head after COVID-19 steroid treatment compared to steroid-associated osteonecrosis.BMC musculoskeletal disorders · 2025Article
- Osteonecrosis following Steroid Therapy in COVID-19 Patients: An Outlook on the Emerging Problem.Hip & pelvis · 2025Review
- Spontaneous Osteonecrosis of Knee: A Complication of COVID-19 or An Iatrogenic Side Effect of Steroid Use?Journal of orthopaedic case reports · 2024Article
- Is COVID-19 an independent risk factor for the development of avascular necrosis of the hip? A retrospective study to evaluate the factors associated with avascular necrosis of the hip in patients who had COVID-19 infection.International orthopaedics · 2024Article
- A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Knee osteonecrosis after SARS-CoV-2 infection: a systematic case-based review.Annals of joint · 2024Review
- Glucocorticoid-induced activation of NOX/ROS/NF-κB signaling in MSCs contributes to the development of GONFH.Apoptosis : an international journal on programmed cell death · 2023Article
- Identification of key genes and pathways associated with gender difference in osteonecrosis of the femoral head based on bioinformatics analysis.Journal of musculoskeletal & neuronal interactions · 2023Article
- Screening for Femoral Head Osteonecrosis Following COVID-19: Is It Worth It?The archives of bone and joint surgery · 2023Article
- The painful joint after COVID-19 treatment: A study on joint osteonecrosis following COVID-19-related corticosteroid use.Joint diseases and related surgery · 2023Article
- Postacute sequelae of SARS-CoV-2 infection. Osteonecrosis must not be overlooked.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corticosteroid use has been implicated in the development of osteonecrosis of the femoral head (ONFH). The exact mechanism and predisposing factors such as age, gender, dosage, type and combination of steroid treatment remain controversial. Between March and July 2003, a total of 539 patients with severe acute respiratory syndrome (SARS) were treated with five different types of steroid. There were 129 men (24%) and 410 women (76%) with a mean age of 33.7 years (21 to 59). Routine screening was undertaken with radiographs, MRI and/or CT to determine the incidence of ONFH. Of the 129 male patients with SARS, 51 (39.5%) were diagnosed as suffering from ONFH, compared with only 79 of 410 female patients (19.3%). The incidence of ONFH in the patients aged between 20 and 49 years was much higher than that of the group aged between 50 and 59 years (25.9% (127 of 491) versus 6.3% (3 of 48); p = 0.018). The incidence of ONFH in patients receiving one type of steroid was 12.5% (21 of 168), which was much lower than patients receiving two different types (28.6%; 96 of 336) or three different types of steroid (37.1%; 13 of 35).
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