SynthesisClinical & experimental metastasis2014
Genetics of breast cancer bone metastasis: a sequential multistep pattern.
Synthesis in Clinical & experimental metastasis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Traditional Chinese medicine in the treatment of breast Cancer.Molecular cancer · 2025Review
- Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions.Cell & bioscience · 2023Review
- The relationship between the Hippo signaling pathway and bone metastasis of breast cancer.Frontiers in oncology · 2023Review
- Metastatic and non-metastatic melanoma imaging using Sgc8-c aptamer PTK7-recognizer.Scientific reports · 2021Article
- miRNA-148a and miRNA-30c expressions as potential biomarkers in breast cancer patients.Biochemistry and biophysics reports · 2021Article
- Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.Clinical & experimental metastasis · 2020Article
- Trends in Bone Metastasis Modeling.Cancers · 2020Review
- Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons.Frontiers in bioengineering and biotechnology · 2020Review
- Causal Inference Network of Genes Related with Bone Metastasis of Breast Cancer and Osteoblasts Using Causal Bayesian Networks.Journal of bone metabolism · 2018Article
- Engineering 3D approaches to model the dynamic microenvironments of cancer bone metastasis.Bone research · 2018Review
- Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?International journal of molecular sciences · 2016Review
- In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone.International journal of molecular sciences · 2016Review
- SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2016Article
- Pathogenesis of Breast Cancer Metastasis to Brain: a Comprehensive Approach to the Signaling Network.Molecular neurobiology · 2016Review
- The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.BMC cancer · 2015Article
- IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study.BMC gastroenterology · 2015Article
- Cytokines as Mediators of Pain-Related Process in Breast Cancer.Mediators of inflammation · 2015Review
- Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.The Journal of biological chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone metastasis accounts for the vast majority of breast cancer (BC) metastases, and is related to a high rate of morbidity and mortality. A number of seminal studies have uncovered gene expression signatures involved in BC development and bone metastasis; each of them points at a distinct step of the 'invasion-metastasis cascade'. In this review, we provide most recently discovered functions of sets of genes that are selected from widely accepted gene signatures that are implicate in BC progression and bone metastasis. We propose a possible sequential pattern of gene expression that may lead a benign primary breast tumor to get aggressiveness and progress toward bone metastasis. A panel of genes which primarily deal with features like DNA replication, survival, proliferation, then, angiogenesis, migration, and invasion has been identified. TGF-β, FGF, NFκB, WNT, PI3K, and JAK-STAT signaling pathways, as the key pathways involved in breast cancer development and metastasis, are evidently regulated by several genes in all three signatures. Epithelial to mesenchymal transition that is also an important mechanism in cancer stem cell generation and metastasis is evidently regulated by these genes. This review provides a comprehensive insight regarding breast cancer bone metastasis that may lead to a better understanding of the disease and take step toward better treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.