Evidence map›Paper›PMID 24492712›Full record

ReviewCold Spring Harbor perspectives in biology2014

Neuronal signaling through endocytosis.

Katharina E Cosker, Rosalind A Segal

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 159 citations in OpenAlex.

  1. Review
  2. Late Endosome Transport by RILP-RAB7A Promotes Dendrite Arborization Independently of Degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Late endosome transport by RILP-RAB7A promotes dendrite arborization.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Differential effects ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  10. PLC-γ-CaFrontiers in molecular neuroscience · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Selective motor activation in organelle transport along axons.Nature reviews. Molecular cell biology · 2022
    Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Katharina E CoskerDepartment of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115.
Rosalind A Segal
Dana-Farber Cancer Institute · USHarvard University · US

Funding

Spatial Considerations in Neuronal Survival SignalsR01NS050674 · NINDS · DANA-FARBER CANCER INSTITUTE · PI SEGAL, ROSALIND A. · 2005 to 2021
$5.9M
NINDS NIH HHS R01 NS050674
6 · The paper itself

Abstract

The distinctive morphology of neurons, with complex dendritic arbors and extensive axons, presents spatial challenges for intracellular signal transduction. The endosomal system provides mechanisms that enable signaling molecules initiated by extracellular cues to be trafficked throughout the expanse of the neuron, allowing intracellular signals to be sustained over long distances. Therefore endosomes are critical for many aspects of neuronal signaling that regulate cell survival, axonal growth and guidance, dendritic branching, and cell migration. An intriguing characteristic of neuronal signal transduction is that endosomal trafficking enables physiological responses that vary based on the subcellular location of signal initiation. In this review, we will discuss the specialized mechanisms and the functional significance of endosomal signaling in neurons, both during normal development and in disease.

Indexed as

Cell SurvivalCharcot-Marie-Tooth DiseaseEndosomesHumansHuntington DiseaseNerve Growth FactorsNeuronsrab GTP-Binding ProteinsReceptor, trkASignal TransductionNerve Growth Factorsrab GTP-Binding ProteinsReceptor, trkA

Identifiers

PMID24492712
PMCPMC3941234
OpenAlexW2164965868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.