ArticleThe Journal of biological chemistry2014
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 105 citations in OpenAlex.
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- The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types.BMC genomics · 2024Article
- Defensive behavior is linked to altered surface chemistry following infection in a termite society.Scientific reports · 2023Article
- Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies.PLoS genetics · 2023Article
- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration.Aging cell · 2022Review
- Sensing microbial infections in the Drosophila melanogaster genetic model organism.Immunogenetics · 2022Review
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- Critical Roles of Spätzle5 in Antimicrobial Peptide Production AgainstFrontiers in immunology · 2021Article
- Host-pathogen interaction after infection of Galleria mellonella with the filamentous fungus Beauveria bassiana.Insect science · 2020Article
- Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Thioester-containing Proteins in theInsects · 2020Review
- Molecular and Functional Analysis of Pore-Forming Toxin Monalysin From Entomopathogenic BacteriumFrontiers in immunology · 2020Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- Insect anal droplets contain diverse proteins related to gut homeostasis.BMC genomics · 2018Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is an evolutionarily conserved mechanism that removes damaged or unwanted cells, effectively maintaining cellular homeostasis. It has long been suggested that a deficiency in this type of naturally occurring cell death could potentially lead to necrosis, resulting in the release of endogenous immunogenic molecules such as damage-associated molecular patterns (DAMPs) and a noninfectious inflammatory response. However, the details about how danger signals from apoptosis-deficient cells are detected and translated to an immune response are largely unknown. In this study, we found that Drosophila mutants deficient for Dronc, the key initiator caspase required for apoptosis, produced the active form of the endogenous Toll ligand Spätzle (Spz). We speculated that, as a system for sensing potential DAMPs in the hemolymph, the dronc mutants constitutively activate a proteolytic cascade that leads to Spz proteolytic processing. We demonstrated that Toll signaling activation required the action of Persephone, a CLIP domain serine protease that usually reacts to microbial proteolytic activities. Our findings show that the Persephone proteolytic cascade plays a crucial role in mediating DAMP-induced systemic responses in apoptosis-deficient Drosophila mutants.
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