ArticleMarine drugs2014
Fucoidan extracted from Fucus evanescens prevents endotoxin-induced damage in a mouse model of endotoxemia.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Innovative Applications of Marine Macroalgae Polysaccharides in Tissue Engineering and Drug Delivery: A Review Study.Health science reports · 2025Article
- Seaweed in the Diet as a Source of Bioactive Metabolites and a Potential Natural Immunity Booster: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Optimum Processing Conditions for Flavor-Enhancing Green Laver Chips Using Reaction Flavor Technology.Foods (Basel, Switzerland) · 2024Article
- Anti-Inflammatory Activity of Fucan fromMarine drugs · 2023Article
- Recent insights of fucoidan probiotic and its effect on gut microbiota.EXCLI journal · 2023Article
- The Anti-Inflammatory Effect of Carrageenan/Echinochrom Complex at Experimental Endotoxemia.International journal of molecular sciences · 2022Article
- Protective effects of fucoidan against 4-nitroquinolin-1-oxide provoked genetic damage in mouse bone marrow cells.Environmental science and pollution research international · 2020Article
- Inhibitory Effects of Carrageenans on Endotoxin-Induced Inflammation.Marine drugs · 2020Article
- Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis.Nutrients · 2020Article
- Effects of CrudeMarine drugs · 2019Article
- Ascophyllan Induces Activation of Natural Killer Cells in Mice In Vivo and In Vitro.Marine drugs · 2019Article
- Article
- The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition.Oncotarget · 2017Article
- Therapies from Fucoidan: An Update.Marine drugs · 2015Review
- Fucoidan Extracts Ameliorate Acute Colitis.PloS one · 2015Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important problem of treating patients with endotoxemia is to find drugs to reduce the negative effects of endotoxin on the organism. We tested fucoidan (sulfated polysaccharide) from the brown alga Fucus evanescens as a potential drug in a mouse model of endotoxemia inducted by lipopolysaccharide (LPS). The survival time of mice injected with LPS increased under fucoidan treatment compared with the group of mice injected with LPS only. The preventive administration of fucoidan to mice with endotoxemia resulted in inhibition of increased levels of proinflammatory cytokines (TNFα and IL-6), as well as decreasing of the processes of hypercoagulability. The parenteral or per os administration of fucoidan resulted in decreasing the degree of microcirculatory disorders and secondary dystrophic-destructive changes in parenchymal organs of mice with endotoxemia. Taken together, these results demonstrate that fucoidan prevents endotoxin-induced damage in a mouse model of endotoxemia and increases the mice's resistance to LPS.
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