ArticleTransplantation2014
Telomere length of recipients and living kidney donors and chronic graft dysfunction in kidney transplants.
Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.PloS one · 2016Trial
- Association Between Metabolic Syndrome Components, Clinical Characteristics, and Telomere Length: Factor Analysis of Mixed Data Based Cluster Analysis of LIPIDOGEN2015 Cross-Sectional Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Senescence-induced p21Cell discovery · 2025Article
- Telomere length across the spectrum of metabolic health: an analysis from the LIPIDOGEN2015 study.Archives of medical science : AMS · 2025Article
- Telomere Length, Telomerase Activity, and Vaginal Microbiome in Patients with HPV-Related Precancerous Lesions.International journal of molecular sciences · 2024Article
- Telomeres and telomerase in endometrial cancer and hyperplasia.Archives of medical science : AMS · 2024Article
- Prediction of Kidney Graft Rejection Using Artificial Neural Network.Healthcare informatics research · 2017Article
- Concepts of Genomics in Kidney Transplantation.Current transplantation reports · 2017Article
- Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Telomere Length Assessment for Prediction of Organ Transplantation Outcome. Future or Failure: A Review of the Literature.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
- Identifying Important Risk Factors for Survival in Kidney Graft Failure Patients Using Random Survival Forests.Iranian journal of public health · 2016Article
- Effect of delayed graft function, acute rejection and chronic allograft dysfunction on kidney allograft telomere length in patients after transplantation: a prospective cohort study.BMC nephrology · 2015Article
- Biological pathways and potential targets for prevention and therapy of chronic allograft nephropathy.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA biological marker that would allow clinicians to determine the length of time an allograft will remain functional after transplantation would greatly aid the ability to stratify donors by risk and to use biologically "young" allografts in young recipients, maximizing the use of this rare resource. Telomere length (TL) has been proposed to be such a marker to determine the biological age of a tissue.
methodsWe genotyped DNA from 1805 recipients and 1038 living kidney donors for TL to determine the association of TL with acute rejection (AR), chronic graft dysfunction (CGD), and graft failure of kidney allografts. DNA was isolated from peripheral blood white blood cells and TL was measured in DNA using the multiplexed monochrome quantitative polymerase chain reaction assay.
resultsAs has been previously shown, we found a significant association between log-transformed TL and donor age (P=3.8×10) and recipient age (P=5.6×10). Univariate and multivariate analysis did not show any significant associations between log-transformed TL in donor or recipient DNA with AR, CGD, or graft failure, although we did observe an association between donor chronological age and CGD (P=0.018).
conclusionAlthough older allografts have been shown to be at greater risk for AR and CGD, this does not appear to be associated with shorter TL. Different markers will need to be identified to determine how biological age impacts transplant outcome, such as age-related fibrosis or tubular atrophy and tubular loss.
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