ArticleAntimicrobial agents and chemotherapy2014
Bactericidal activity of N-chlorotaurine against biofilm-forming bacteria grown on metal disks.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Antimicrobial Efficacy and Stability of an N-Chlorotaurine Gel for Chronic Wound Treatment.International journal of molecular sciences · 2025Article
- Article
- Long-Term Stability and Efficacy of NCT Solutions.International journal of molecular sciences · 2024Article
- Activity ofInternational journal of molecular sciences · 2024Article
- Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases.Advances in experimental medicine and biology · 2022Review
- Activity ofAntibiotics (Basel, Switzerland) · 2021Article
- Successful treatment of a unique chronic multi-bacterial scalp infection withAccess microbiology · 2020Article
- Progress in Definition, Prevention and Treatment of Fungal Infections in Cystic Fibrosis.Mycopathologia · 2018Review
- N-Chlorotaurine, a Promising Future Candidate for Topical Therapy of Fungal Infections.Mycopathologia · 2018Review
- Bactericidal and Fungicidal Activity ofAntimicrobial agents and chemotherapy · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many orthopedic surgeons consider surgical irrigation and debridement with prosthesis retention as a treatment option for postoperative infections. Usually, saline solution with no added antimicrobial agent is used for irrigation. We investigated the activity of N-chlorotaurine (NCT) against various biofilm-forming bacteria in vitro and thereby gained significant information on its usability as a soluble and well-tolerated active chlorine compound in orthopedic surgery. Biofilms of Staphylococcus aureus were grown on metal alloy disks and in polystyrene dishes for 48 h. Subsequently, they were incubated for 15 min to 7 h in buffered solutions containing therapeutically applicable concentrations of NCT (1%, 0.5%, and 0.1%; 5.5 to 55 mM) at 37°C. NCT inactivated the biofilm in a time- and dose-dependent manner. Scanning electron microscopy revealed disturbance of the biofilm architecture by rupture of the extracellular matrix. Assays with reduction of carboxanilide (XTT) showed inhibition of the metabolism of the bacteria in biofilms. Quantitative cultures confirmed killing of S. aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa biofilms on metal alloy disks by NCT. Clinical isolates were slightly more resistant than ATCC type strains, but counts of CFU were reduced at least 10-fold by 1% NCT within 15 min in all cases. NCT showed microbicidal activity against various bacterial strains in biofilms. Whether this can be transferred to the clinical situation should be the aim of future studies.
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