ArticleJPEN. Journal of parenteral and enteral nutrition2015
Association between prehospital vitamin D status and hospital-acquired Clostridium difficile infections.
Article in JPEN. Journal of parenteral and enteral nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2022Trial
- Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths.Critical care (London, England) · 2019Trial
- Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults.Contemporary clinical trials · 2016Trial
- Serum 25-hydroxyvitamin D levels andArchives of medical science : AMS · 2026Article
- Investigating the Correlation Between Clostridioides difficile Infection and Vitamin D Deficiency.Cureus · 2023Article
- The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion.Nutrients · 2022Review
- Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview.Frontiers in nutrition · 2022Review
- The impact of maternal and early life malnutrition on health: a diet-microbe perspective.BMC medicine · 2020Review
- Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases.Clinical microbiology reviews · 2019Review
- Plasma 25-Hydroxyvitamin D and the Longitudinal Risk of Sepsis in the REGARDS Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Intestinal calcium and bile salts facilitate germination of Clostridium difficile spores.PLoS pathogens · 2017Article
- Associations Between Vitamin D Level and Hospitalizations With and Without an Infection in a National Cohort of Medicare Beneficiaries.American journal of epidemiology · 2016Article
- Addition of 25-hydroxyvitamin D levels to the Deyo-Charlson Comorbidity Index improves 90-day mortality prediction in critically ill patients.Journal of intensive care · 2016Article
- Admission vitamin D status is associated with discharge destination in critically ill surgical patients.Annals of intensive care · 2015Article
- Serum 25-Hydroxyvitamin D Levels are not Associated with Adverse Outcomes in Clostridium Difficile Infection.Infectious disease reports · 2015Article
- Vitamin D status and the risk for hospital-acquired infections in critically ill adults: a prospective cohort study.PloS one · 2015Observational
- Vitamin D deficiency is associated with community-acquired clostridium difficile infection: a case-control study.BMC infectious diseases · 2014Article
- Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases.Alimentary pharmacology & therapeutics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether preadmission 25-hydroxyvitamin D (25(OH)D) levels are associated with the risk of hospital-acquired Clostridium difficile infection (HACDI). MATERIALS AND
methodsOur retrospective cohort study focused on 568 adult patients from 2 Boston teaching hospitals between August 1993 and November 2006. All patients had 25(OH)D levels measured before hospitalization and were at risk for HACDI (defined as the presence of C difficile toxin A or B in stool samples obtained >48 hours after hospitalization). We performed multivariable regression analyses to test the association of prehospital 25(OH)D levels with HACDI while adjusting for clinically relevant covariates.
resultsIn these 568 patients, mean (SD) 25(OH)D level was 19 (12) ng/mL, and 11% of patients met criteria for incident HACDI. Following adjustment for age, sex, race (nonwhite vs white), patient type (medical vs surgical), and Deyo-Charlson index, patients with 25(OH)D levels <10 ng/mL had higher odds of HACDI (odds ratio [OR], 2.90; 95% confidence interval [CI], 1.01-8.34) compared with patients with 25(OH)D levels ≥30 ng/mL. When patients with HACDI were analyzed relative to a larger patient cohort without HACDI (n = 5047), those with 25(OH)D levels <10 ng/mL (OR, 4.96; 95% CI, 1.84-13.38) and 10-19.9 ng/mL (OR, 3.36; 95% CI, 1.28-8.85) had higher adjusted odds of HACDI compared with patients with 25(OH)D levels ≥30 ng/mL.
conclusionsIn our cohort of adult patients, vitamin D status before hospital admission was inversely associated with the risk of developing HACDI. These data support the need for randomized, controlled trials to test the role of vitamin D supplementation to prevent HACDI.
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