Evidence map›Paper›PMID 24491834›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2014

Gene expression in teratogenic exposures: a new approach to understanding individual risk.

Claudia Kappen, J Michael Salbaum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Epigenetic Changes in Gestational Diabetes Mellitus.International journal of molecular sciences · 2021
    Review
  2. Article
  3. The status of diabetic embryopathy.Upsala journal of medical sciences · 2016
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Claudia KappenDepartment of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, United States. Electronic address: Claudia.Kappen@pbrc.edu.
J Michael SalbaumLaboratory of Regulation of Gene Expression, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, United States.

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
THE ROLE OF PROTEIN MALNUTRITION ON CIRCADIAN PHYSIOLOGY OF C57BL/6J MOUSE DAMSP20RR021945 · NCRR · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2006 to 2011
$9.5M
Mentoring Obesity and Diabetes Research in LouisianaP20GM103528 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2012 to 2015
$8.8M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8M
MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHYR01HD037804 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KAPPEN, CLAUDIA T · 1998 to 2010
$2.5M
Neural tube defects in diabetic pregnancyR01HD055528 · NICHD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI SALBAUM, J MICHAEL · 2007 to 2011
$1.8M
NCRR NIH HHS P20 RR021945NICHD NIH HHS R01 HD037804NICHD NIH HHS R01-HD037804NICHD NIH HHS R01 HD055528NICHD NIH HHS R01-HD055528NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30-DK072476NIGMS NIH HHS P20 GM103528NIGMS NIH HHS P20-GM103528NIGMS NIH HHS P30 GM118430
6 · The paper itself

Abstract

The phenomenon of partial or incomplete penetrance is common to many paradigms of exposure to teratogens, where only some of the exposed individuals exhibit developmental defects. We here argue that the most widely used experimental approaches in reproductive toxicology do not take partial penetrance into account, and are thus likely to miss differences between affected and unaffected individuals that contribute to susceptibility for teratogenesis. We propose that focus on the variation between exposed individuals could help to discover factors that may play a causative role for abnormal developmental processes that occur with incomplete penetrance.

Indexed as

Gene Expression Regulation, DevelopmentalAbnormalities, Drug-InducedAnimalsGenetic VariationMiceRiskTeratogensTeratogensGene expressionMaternal diabetesMouse modelNeural tube defectPhenotypeSusceptibilityTeratogen exposureVariation

Identifiers

PMID24491834
PMCPMC4066898

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.