Relative specificity: all substrates are not created equal.

Yan Zeng

Abstract readReview

In one paragraph

Review in Genomics, proteomics & bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Relative specificity as an important consideration in the big data era.Frontiers in genetics · 2022
Article
Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer.Frontiers in molecular biosciences · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Yan ZengDepartment of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: zengx033@umn.edu.

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012

$14.0M

Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV diR01DA031202 · NIDA · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM, ROY, SABITA · 2011 to 2015

$1.7M

NIDA NIH HHS 5P50-DA011806-12NIDA NIH HHS P50 DA011806NIDA NIH HHS R01 DA031202NIDA NIH HHS R01DA031202

6 · The paper itself

Abstract

A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functions, even though it has not been examined explicitly in most complex biochemical systems. This essay reviews several recent large-scale studies that investigate protein folding, signal transduction, RNA binding, translation and transcription in the context of relative specificity. These results and others support a pervasive role of relative specificity in diverse biological processes. It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems, which has significant implications in disease processes as well.

Indexed as

Protein BiosynthesisRNA StabilitySignal TransductionTranscription, GeneticAnimalsGenomeHumansSubstrate SpecificityBiochemical activityBiological systemsRelative specificitySubstrates

Identifiers

PMID24491634

DOI10.1016/j.gpb.2014.01.001

PMCPMC4411342

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.