Evidence map›Paper›PMID 24491522›Full record

ReviewDevelopmental and comparative immunology2014

Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions.

Remi L Gratacap, Robert T Wheeler

Abstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Current research in parasitology & vector-borne diseases · 2025
    Review
  2. Review
  3. Inflammation in Development and Aging: Insights from the Zebrafish Model.International journal of molecular sciences · 2024
    Review
  4. Recent Advances with Fish Microsporidia.Experientia supplementum (2012) · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Animal Models to Study Mucormycosis.Journal of fungi (Basel, Switzerland) · 2019
    Review
  10. The Zebrafish as a Model Host for Invasive Fungal Infections.Journal of fungi (Basel, Switzerland) · 2018
    Review
  11. Article
  12. Article
  13. Use of zebrafish to studyDisease models & mechanisms · 2018
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Remi L GratacapDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, ME 04469, United States.
Robert T WheelerDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, ME 04469, United States; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, United States. Electronic address: robert.wheeler@umit.maine.edu.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
WNT SIGNALING IN THE DEVELOPING GASTROINTESTINAL TRACTP20RR016463 · NCRR · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI HAND, PATRICIA H. · 2001 to 2011
$41.0M
Genetics and visualization of innate host response to C. albicans infection in viR15AI094406 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2012 to 2012
$422k
NCRR NIH HHS 5P20RR016463NCRR NIH HHS P20 RR016463NIAID NIH HHS R15 AI094406NIAID NIH HHS R15AI094406NIGMS NIH HHS 8P20GM103423NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

Unique imaging tools and practical advantages have made zebrafish a popular model to investigate in vivo host-pathogen interactions. These studies have uncovered details of the mechanisms involved in several human infections. Until recently, studies using this versatile host were limited to viral and prokaryotic pathogens. Eukaryotic pathogens are a diverse group with a major impact on the human and fish populations. The relationships of eukaryote pathogens with their hosts are complex and many aspects remain obscure. The small and transparent zebrafish, with its conserved immune system and amenability to genetic manipulation, make it an exciting model for quantitative study of the core strategies of eukaryotic pathogens and their hosts. The only thing to do now is realize its potential for advancement of biomedical and aquaculture research.

Indexed as

Disease Models, AnimalHost-Pathogen InteractionsZebrafishAnimalsEukaryotaHumansInfectionsCandidaFungalHelminthHost–pathogenImmunityProtozoanZebrafish

Identifiers

PMID24491522
PMCPMC4028364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.