Evidence map›Paper›PMID 24491484›Full record

ArticleNeuromuscular disorders : NMD2014

Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.

R J Willcocks, I A Arpan, S C Forbes, D J Lott, C R Senesac, E Senesac, J Deol, W T Triplett, C Baligand, M J Daniels and 3 more

3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromuscular disorders : NMD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01484678 recruitingnot on this mapstarted 2020, after this paper: background citation

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

TypeobservationalSponsorUniversity of FloridaRan2020 to 2026Enrolled550ConditionsDuchenne Muscular Dystrophy, Becker Muscular Dystrophy
NCT05618080 active not recruitingnot on this mapstarted 2024, after this paper: background citation

GRASP-01-003: Trial Readiness and Endpoint Assessment in LGMD R1

TypeobservationalSponsorVirginia Commonwealth UniversityRan2024 to 2028Enrolled100ConditionsCalpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A, Limb Girdle Muscular Dystrophy, Limb Girdle Muscular Dystrophy Type R1, LGMD2A
NCT05989620 recruitingnot on this mapstarted 2023, after this paper: background citation

Long-Term Development of Muscular Dystrophy Outcome Assessments (GRASP-01-005)

TypeobservationalSponsorVirginia Commonwealth UniversityRan2023 to 2029Enrolled1,000ConditionsLGMD1B, LGMD1C, LGMD1D, LGMD1E
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

R J WillcocksDepartment of Physical Therapy, University of Florida, USA. Electronic address: rw254@phhp.ufl.edu.
I A ArpanDepartment of Physical Therapy, University of Florida, USA.
S C ForbesDepartment of Physical Therapy, University of Florida, USA.
D J LottDepartment of Physical Therapy, University of Florida, USA.
C R SenesacDepartment of Physical Therapy, University of Florida, USA.
E SenesacDepartment of Physical Therapy, University of Florida, USA.
J DeolDepartment of Physical Therapy, University of Florida, USA.
W T TriplettDepartment of Physiology and Functional Genomics, University of Florida, USA.
C BaligandDepartment of Physiology and Functional Genomics, University of Florida, USA.
M J DanielsDivision of Statistics & Scientific Computation, University of Texas at Austin, USA.
H L SweeneyDepartment of Physiology, University of Pennsylvania School of Medicine, USA.
G A WalterDepartment of Physiology and Functional Genomics, University of Florida, USA.
K VandenborneDepartment of Physical Therapy, University of Florida, USA.
University of Florida · USUniversity of Pennsylvania · US

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Magnetic Resonance Imaging and Biomarkers for Muscular DystropyR01AR056973 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2010 to 2024
$20.2M
MR Monitoring of PTC124 Treatment in DMDRC1AR058189 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2009 to 2010
$840k
NIAMS NIH HHS AR058189-01NIAMS NIH HHS R01 AR056973NIAMS NIH HHS RC1 AR058189NIAMS NIH HHS U54 AR052646NIAMS NIH HHS U54AR052646
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is characterized by an increased muscle damage and progressive replacement of muscle by noncontractile tissue. Both of these pathological changes can lengthen the MRI transverse proton relaxation time (T2). The current study measured longitudinal changes in T2 and its distribution in the lower leg of 16 boys with DMD (5-13years, 15 ambulatory) and 15 healthy controls (5-13years). These muscles were chosen to allow extended longitudinal monitoring, due to their slow progression compared with proximal muscles in DMD. In the soleus muscle of boys with DMD, T2 and the percentage of pixels with an elevated T2 (⩾2SD above control mean T2) increased significantly over 1year and 2years, while the width of the T2 histogram increased over 2years. Changes in soleus T2 variables were significantly greater in 9-13years old compared with 5-8years old boys with DMD. Significant correlations between the change in all soleus T2 variables over 2years and the change in functional measures over 2years were found. MRI measurement of muscle T2 in boys with DMD is sensitive to disease progression and shows promise as a clinical outcome measure.

Indexed as

LegAdipose TissueAdolescentChildDisease ProgressionHumansImage Processing, Computer-AssistedLocomotionLongitudinal StudiesMagnetic Resonance ImagingMaleMuscle, SkeletalMuscular Dystrophy, DuchenneSeverity of Illness Index30 Foot walkDuchenne muscular dystrophyMagnetic resonance imagingTransverse relaxation time

Identifiers

PMID24491484
PMCPMC4277599
OpenAlexW2018722071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.