ArticleAmerican journal of ophthalmology2014
Risk factors associated with reticular pseudodrusen versus large soft drusen.
Article in American journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Association between four anthropometric indices with age-related Macular Degeneration from NHANES 2005-2008.Lipids in health and disease · 2025Article
- Prevalence and determinants of subretinal drusenoid deposits in patients' first-degree relatives.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Current Perspectives on Type 3 Macular Neovascularization due to Age-Related Macular Degeneration.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2024Review
- Association between Subretinal Drusenoid Deposits and Age-Related Macular Degeneration in Multimodal Retinal Imaging.Journal of clinical medicine · 2023Article
- Multimodal Imaging of Reticular Pseudodrusen in Turkish Patients.Turkish journal of ophthalmology · 2023Article
- Serum miRNA modulations indicate changes in retinal morphology.Frontiers in molecular neuroscience · 2023Article
- Evaluation of the microperimetry in eyes with cuticular drusen.Scientific reports · 2022Article
- Gender as an effect modifier in the relationship between hypertension and reticular pseudodrusen in patients with early or intermediate age-related macular degeneration.International journal of ophthalmology · 2022Article
- Increased Systemic C-Reactive Protein Is Associated With Choroidal Thinning in Intermediate Age-Related Macular Degeneration.Translational vision science & technology · 2021Article
- Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study.Molecular vision · 2021Article
- Drusen and pachydrusen: the definition, pathogenesis, and clinical significance.Eye (London, England) · 2021Review
- Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration.Translational vision science & technology · 2020Article
- Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Incidence and Risk Factors of Reticular Pseudodrusen Using Multimodal Imaging.JAMA ophthalmology · 2020Article
- Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging.BMJ open ophthalmology · 2020Article
- Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen-the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002-2006).Eye (London, England) · 2019Article
- Prevalence of reticular pseudodrusen in an elderly UK Caucasian population-The Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002-2006).Eye (London, England) · 2018Article
- Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials.JAMA ophthalmology · 2018Article
- Dietary, environmental, and genetic risk factors of Extensive Macular Atrophy with Pseudodrusen, a severe bilateral macular atrophy of middle-aged patients.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen without reticular pseudodrusen.
designProspective case-case comparison.
methodsIn a clinical practice setting, patients with AMD were sequentially screened using clinical examination and scanning laser ophthalmoscopy imaging to prospectively identify subjects (n = 73) with the phenotypes of (1) reticular pseudodrusen without large soft drusen (n = 30) or (2) large soft drusen without reticular pseudodrusen (n = 43). Subjects were genotyped for 2 alleles associated with AMD, age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH). A questionnaire was administered to collect history of smoking, hypertension, diabetes, and hyperlipidemia, as well as personal and family history of AMD.
resultsThe reticular pseudodrusen group was older (median age 87 vs 81 years, P = .04) and had more female subjects (83.3% vs 48.8%, P = .003), later ages of AMD onset (83 vs 70 years, P = .0005), and a greater frequency of hypertension (76.7% vs 55.8%, P = .08). No significant differences were found in the distribution of the ARMS2 risk allele (P = .4) between the reticular pseudodrusen (homozygous = 20.0%; heterozygous = 56.7%) and large soft drusen (homozygous = 19.0%; heterozygous = 42.9%) phenotypes, or in the distribution of the CHF risk allele (P = .7) between the reticular pseudodrusen (homozygous = 26.7%; heterozygous = 56.7%) and large soft drusen (homozygous = 21.4%; heterozygous = 66.7%) phenotypes.
conclusionsThe reticular pseudodrusen phenotype was associated with increased age, later age of AMD onset, and female sex.
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