Evidence map›Paper›PMID 24491308›Full record

SynthesisEuropean urology2014

Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

Rufus Cartwright, Altaf Mangera, Kari A O Tikkinen, Prabhakar Rajan, Jori Pesonen, Anna C Kirby, Ganesh Thiagamoorthy, Chris Ambrose, Juan Gonzalez-Maffe, Phillip R Bennett and 5 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Vitamin D and incident urinary incontinence in older adults.European journal of clinical nutrition · 2016
    Article
  13. The Epidemiology of Pelvic Floor Disorders and Childbirth: An Update.Obstetrics and gynecology clinics of North America · 2016
    Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 4 countries.

Rufus CartwrightDepartment of Epidemiology and Biostatistics and Department of Urogynaecology, Imperial College London, London, UK. Electronic address: r.cartwright@imperial.ac.uk.
Altaf MangeraDepartment of Urology Research, University of Sheffield, Sheffield, UK.
Kari A O TikkinenDepartment of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland, and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Prabhakar RajanBeatson Institute for Cancer Research, University of Glasgow, Glasgow, UK.
Jori PesonenDepartment of Urology, Tampere University Hospital, and School of Medicine, University of Tampere, Tampere, Finland.
Anna C KirbyDepartment of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA, and Department of Obstetrics and Gynecology, Kaiser Permanente, San Diego, CA, USA.
Ganesh ThiagamoorthyDepartment of Urogynaecology, King's College London, London, UK.
Chris AmbroseUniversity College London Medical School, London, UK.
Juan Gonzalez-MaffeClinical Trials Unit, Imperial College London, London, UK.
Phillip R BennettInstitute for Reproductive and Developmental Biology, Imperial College London, London, UK.
Tom PalmerDivision of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Andrew WalleySection of Genomic Medicine, National Heart and Lung Institute and Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA), Centre for Environment and Health, School of Public Health, Imperial College, London, UK, Institute of Health Sciences and Biocentre, Oulu, University of Oulu, Finland, Unit of Primary Care, Oulu University, Hospital, Oulu, Finland and Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Vik KhullarDepartment of Urogynaecology, Imperial College London, London, UK.
Chris ChappleDepartment of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Imperial College London · GBKaiser Permanente San Diego Medical Center · USKing's College London · GBSheffield Teaching Hospitals NHS Foundation Trust · GBTampere University · FIUniversity College London · GBUniversity of Glasgow · GBUniversity of Helsinki · FIUniversity of Oulu · FIUniversity of Sheffield · GBUniversity of Warwick · GB

Funding

Medical Research Council G1100377
6 · The paper itself

Abstract

contextAlthough family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS.

objectiveTo systematically review and meta-analyze studies assessing candidate polymorphisms/genes tested for an association with LUTS, and to assess the strength, consistency, and potential for bias among pooled associations. EVIDENCE ACQUISITION: A systematic search of the PubMed and HuGE databases as well as abstracts of major urologic meetings was performed through to January 2013. Case-control studies reporting genetic associations in men with LUTS were included. Reviewers independently and in duplicate screened titles, abstracts, and full texts to determine eligibility, abstracted data, and assessed the credibility of pooled associations according to the interim Venice criteria. Authors were contacted for clarifications if needed. Meta-analyses were performed for variants assessed in more than two studies. EVIDENCE SYNTHESIS: We identified 74 eligible studies containing data on 70 different genes. A total of 35 meta-analyses were performed with statistical significance in five (ACE, ELAC2, GSTM1, TERT, and VDR). The heterogeneity was high in three of these meta-analyses. The rs731236 variant of the vitamin D receptor had a protective effect for LUTS (odds ratio: 0.64; 95% confidence interval, 0.49-0.83) with moderate heterogeneity (I(2)=27.2%). No evidence for publication bias was identified. Limitations include wide-ranging phenotype definitions for LUTS and limited power in most meta-analyses to detect smaller effect sizes.

conclusionsFew putative genetic risk variants have been reliably replicated across populations. We found consistent evidence of a reduced risk of LUTS associated with the common rs731236 variant of the vitamin D receptor gene in our meta-analyses. PATIENT SUMMARY: Combining the results from all previous studies of genetic variants that may cause urinary symptoms in men, we found significant variants in five genes. Only one, a variant of the vitamin D receptor, was consistently protective across different populations.

Indexed as

Genetic Association StudiesAgedGenetic Predisposition to DiseaseHumansLower Urinary Tract SymptomsMaleMiddle AgedPrevalenceProstatic HyperplasiaRisk FactorsSensitivity and SpecificitySeverity of Illness IndexBenign prostatic hyperplasiaBPHGeneticsGenomicsIncontinence, maleLower urinary tract symptomsLUTSOveractive bladder

Identifiers

PMID24491308
PMCPMC4410299
OpenAlexW2011521085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.