ArticleJournal of immunotoxicology
Pattern recognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis following organic dust extract exposures.
Article in Journal of immunotoxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure.Journal of immunotoxicology · 2023Article
- The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer.Frontiers in immunology · 2022Review
- Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10.Journal of immunotoxicology · 2020Article
- MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease.Respiratory research · 2020Article
- Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Decidua Basalis Mesenchymal Stem Cells Favor Inflammatory M1 Macrophage Differentiation In Vitro.Cells · 2019Article
- The Effect of Inhalant Organic Dust on Bone Health.Current allergy and asthma reports · 2018Review
- Altered immune responses in broiler chicken husbandry workers and their association with endotoxin exposure.Industrial health · 2018Article
- A role for B cells in organic dust induced lung inflammation.Respiratory research · 2017Article
- Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice.Safety (Basel, Switzerland) · 2017Article
- Occupational agriculture organic dust exposure and its relationship to asthma and airway inflammation in adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Review
- Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric Oxide and Protein Kinase-Mediated Inhibition of TACE.Alcoholism, clinical and experimental research · 2016Article
- Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss.PloS one · 2016Article
- MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment.Respiratory research · 2015Article
- Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice.Immunologic research · 2015Article
- Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.Journal of toxicology and environmental health. Part A · 2015Article
- Article
- Influence of farming exposure on the development of asthma and asthma-like symptoms.International immunopharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to agriculture organic dusts, comprised of a diversity of pathogen-associated molecular patterns, results in chronic airway diseases. The multi-functional class A macrophage scavenger receptor (SRA)/CD204 has emerged as an important class of pattern recognition receptors with broad ligand binding ability. The objective was to determine the role of SRA in mediating repetitive and post-inflammatory organic dust extract (ODE)-induced airway inflammation. Wild-type (WT) and SRA knockout (KO) mice were intra-nasally treated with ODE or saline daily for 3 weeks and immediately euthanized or allowed to recover for 1 week. Results show that lung histopathologic changes were increased in SRA KO mice as compared to WT following repetitive ODE exposures marked predominately by increased size and distribution of lymphoid aggregates. After a 1-week recovery from daily ODE treatments, there was significant resolution of lung injury in WT mice, but not SRA KO animals. The increased lung histopathology induced by ODE treatment was associated with decreased accumulation of neutrophils, but greater accumulation of CD4(+) T-cells. The lung cytokine milieu induced by ODE was consistent with a TH1/TH17 polarization in both WT and SRA KO mice. Overall, the data demonstrate that SRA/CD204 plays an important role in the normative inflammatory lung response to ODE, as evidenced by the enhanced dust-mediated injury viewed in the absence of this receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.