ArticleInfluenza and other respiratory viruses2014
Effectiveness of the 2010 and 2011 Southern Hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza-associated acute respiratory infection among Thai adults aged ≥ 50 years.
Article in Influenza and other respiratory viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology.Epidemiology (Cambridge, Mass.) · 2020Pooled it
- Effectiveness of influenza vaccines in preventing severe influenza illness among adults: A systematic review and meta-analysis of test-negative design case-control studies.The Journal of infection · 2017Pooled it
- Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics - a systematic literature review.Influenza and other respiratory viruses · 2016Pooled it
- Potential of the test-negative design for measuring influenza vaccine effectiveness: a systematic review.Expert review of vaccines · 2014Pooled it
- Influenza surveillance and vaccine policy in Thailand-a historical perspective.The Lancet regional health. Southeast Asia · 2025Review
- Article
- Literature review of the epidemiology of influenza B disease in 15 countries in the Asia-Pacific region.Influenza and other respiratory viruses · 2018Review
- The acceptability and validity of self-collected nasal swabs for detection of influenza virus infection among older adults in Thailand.Influenza and other respiratory viruses · 2017Article
- Article
- Assessment of potential public health impact of a quadrivalent inactivated influenza vaccine in Thailand.Influenza and other respiratory viruses · 2016Article
- Seasonal influenza vaccination for children in Thailand: a cost-effectiveness analysis.PLoS medicine · 2015Article
- Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInactivated influenza vaccine (IIV) effectiveness has been evaluated among older adults in high-income countries, but data on IIV effectiveness in low- and middle-income countries remain sparse. We conducted a test-negative case-control analysis to estimate 2010 and 2011 trivalent IIV effectiveness against hospitalization with influenza-associated acute respiratory infection (ARI) among persons aged ≥ 50 years in rural Thailand.
methodsDuring 2010-2011, active surveillance for ARI hospitalization was conducted in two provinces; patients were tested for influenza viruses by real-time RT-PCR. Vaccination status was obtained from vaccine registries. Case and control patients were patients with nasopharyngeal swabs positive and negative for influenza viruses, respectively. Vaccine effectiveness (VE) was estimated for the 6 months after vaccination began. Logistic regression was used to evaluate the association between case status and vaccination while adjusting for age, province, medical conditions, and time.
resultsDuring 2010-2011, there were 1545 patients with ARI, of whom 279 (18%) were influenza-positive case patients and 1266 (82%) were influenza-negative control patients. Of the 279 case patients, 247 (89%) had influenza A and 32 (11%) had influenza B. Fourteen of 279 (5%) case patients and 108 of 1266 (9%) control patients were vaccinated against influenza. The unadjusted IIV effectiveness against hospitalization with influenza-associated ARI was 43% (95% CI: 0-68%); adjusted VE was 47% (95% CI: 5-71%).
conclusionThe 2010 and 2011 IIVs were moderately effective against hospitalization with influenza-associated ARI among Thais aged ≥ 50 years, but IIV coverage was low. Additional efforts are warranted in Thailand to improve IIV uptake in this target group.
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