ArticleBioMed research international2013
The use of fiber-reinforced scaffolds cocultured with Schwann cells and vascular endothelial cells to repair rabbit sciatic nerve defect with vascularization.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Endothelial Cells Differentiated from Human Induced Pluripotent Stem Cells Form Aligned Network Structures in Engineered Neural Tissue.Journal of functional biomaterials · 2025Article
- The Role of Vascularization in Nerve Regeneration: Mechanistic and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Nerve Reconstruction Using ActiGraft Blood Clot in Rabbit Acute Peripheral Injury Model: Preliminary Study.Bioengineering (Basel, Switzerland) · 2024Article
- Vascularized versus Free Nerve Grafts: An Experimental Study on Rats.Journal of personalized medicine · 2023Article
- S-Propargyl-Cysteine Ameliorates Peripheral Nerve Injury through Microvascular Reconstruction.Antioxidants (Basel, Switzerland) · 2023Article
- Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis.Neural regeneration research · 2022Article
- Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration.Bioengineering & translational medicine · 2022Article
- A sciatic nerve gap-injury model in the rabbit.Journal of materials science. Materials in medicine · 2022Article
- A Rabbit Model for Peripheral Nerve Reconstruction Studies Avoiding Automutilation Behavior.Journal of brachial plexus and peripheral nerve injury · 2022Article
- Establishment of a Sheep Model for Hind Limb Peripheral Nerve Injury: Common Peroneal Nerve.International journal of molecular sciences · 2021Article
- The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury.Oxidative medicine and cellular longevity · 2020Review
- Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect.Frontiers in surgery · 2020Article
- Vascularization Strategies for Peripheral Nerve Tissue Engineering.Anatomical record (Hoboken, N.J. : 2007) · 2018Review
- Cartilage Oligomeric Matrix Protein Angiopoeitin-1 Provides Benefits During Nerve Regeneration In Vivo and In Vitro.Annals of biomedical engineering · 2015Article
- Geometrical versus Random β-TCP Scaffolds: Exploring the Effects on Schwann Cell Growth and Behavior.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the feasibility of biodegradable fiber-reinforced 3D scaffolds with satisfactory mechanical properties for the repair of long-distance sciatic nerve defect in rabbits and effects of vascularized graft in early stage on the recovery of neurological function, Schwann cells and vascular endothelial cells were cocultured in the fiber-reinforced 3D scaffolds. Experiment group which used prevascularized nerve complex for the repair of sciatic nerve defect and control group which only cultured with Schwann cells were set. The animals in both groups underwent electromyography to show the status of the neurological function recovery at 4, 8, and 16 weeks after the surgery. Sciatic nerve regeneration and myelination were observed under the light microscope and electron microscope. Myelin sheath thickness, axonal diameter, and number of myelinated nerve fiber were quantitatively analyzed using image analysis system. The recovery of foot ulcer, the velocity of nerve conduction, the number of regenerating nerve fiber, and the recovery of ultrastructure were increased in the experimental group than those in the control group. Prevascularized tissue engineered fiber-reinforced 3D scaffolds for the repair of sciatic nerve defects in rabbits can effectively promote the recovery of neurological function.
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