ArticlePloS one2014
Juvenile hormone biosynthesis gene expression in the corpora allata of honey bee (Apis mellifera L.) female castes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 82 citations in OpenAlex.
- Diet Quality Shapes Metabolic and Immune Transcriptional Responses of Honey Bees Under Acute Heat Stress.Insects · 2026Article
- Honey bee nutritranscriptomics reveals key insights towards precision nutrition.Journal of advanced research · 2026Article
- The serotonin receptor AmFrontiers in physiology · 2026Article
- RNA interference knockdown of the nuclear receptor HR3 suppresses vitellogenesis in Chilo suppressalis.Molecular biology reports · 2025Article
- Comprehensive Genomic Analysis Reveals Novel Transposable Element-Derived MicroRNA Regulating Caste Differentiation in Honeybees.Molecular biology and evolution · 2025Article
- Seasonal Stability Assessment of Reference Genes for Quantitative Real-Time Polymerase Chain Reaction Normalization inCurrent issues in molecular biology · 2024Article
- H3K4me1 Modification Functions in Caste Differentiation in Honey Bees.International journal of molecular sciences · 2023Article
- Decoupling the effects of nutrition, age, and behavioral caste on honey bee physiology, immunity, and colony health.Frontiers in physiology · 2023Article
- The microbiome and gene expression of honey bee workers are affected by a diet containing pollen substitutes.PloS one · 2023Article
- In the battle of the disease: a transcriptomic analysis of European foulbrood-diseased larvae of the Western honey bee (Apis mellifera).BMC genomics · 2022Article
- Genetic Relationships and Signatures of Adaptation to the Climatic Conditions in Populations ofInsects · 2022Article
- Antibiotics Alter the Expression of Genes Related to Behavioral Development in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
- Honeybees are buffered against undernourishment during larval stages.Frontiers in insect science · 2022Article
- Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps.PLoS genetics · 2021Article
- Expression of methyl farnesoate epoxidase (mfe) and juvenile hormone esterase (jhe) genes and their relation to social organization in the stingless bee Melipona interrupta (Hymenoptera: Apidae).Genetics and molecular biology · 2021Article
- Juvenile hormone pathway in honey bee larvae: A source of possible signal molecules for the reproductive behavior ofEcology and evolution · 2021Article
- What happens after a blood meal? A transcriptome analysis of the main tissues involved in egg production in Rhodnius prolixus, an insect vector of Chagas disease.PLoS neglected tropical diseases · 2020Article
- Crosstalk among Indoleamines, Neuropeptides and JH/20E in Regulation of Reproduction in the American Cockroach,Insects · 2020Article
- Diversity of Insect Sesquiterpenoid Regulation.Frontiers in genetics · 2020Review
- Impact of nutritional stress on the honeybee colony health.Scientific reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Juvenile hormone (JH) controls key events in the honey bee life cycle, viz. caste development and age polyethism. We quantified transcript abundance of 24 genes involved in the JH biosynthetic pathway in the corpora allata-corpora cardiaca (CA-CC) complex. The expression of six of these genes showing relatively high transcript abundance was contrasted with CA size, hemolymph JH titer, as well as JH degradation rates and JH esterase (jhe) transcript levels. Gene expression did not match the contrasting JH titers in queen and worker fourth instar larvae, but jhe transcript abundance and JH degradation rates were significantly lower in queen larvae. Consequently, transcriptional control of JHE is of importance in regulating larval JH titers and caste development. In contrast, the same analyses applied to adult worker bees allowed us inferring that the high JH levels in foragers are due to increased JH synthesis. Upon RNAi-mediated silencing of the methyl farnesoate epoxidase gene (mfe) encoding the enzyme that catalyzes methyl farnesoate-to-JH conversion, the JH titer was decreased, thus corroborating that JH titer regulation in adult honey bees depends on this final JH biosynthesis step. The molecular pathway differences underlying JH titer regulation in larval caste development versus adult age polyethism lead us to propose that mfe and jhe genes be assayed when addressing questions on the role(s) of JH in social evolution.
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