Trial reportPloS one2014
The personal human oral microbiome obscures the effects of treatment on periodontal disease.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The Effect of Non-Surgical Periodontal Therapy on Subgingival Microbiota: A Systematic Review and Meta-Analysis.Journal of periodontal research · 2025Pooled it
- Therapeutic Strategies and Genetic Implications for Periodontal Disease Management: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Using next-generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review.Oral diseases · 2021Pooled it
- No differences in microbiome changes between anti-adhesive and antibacterial ingredients in toothpastes during periodontal therapy.Journal of periodontal research · 2019Trial
- Trial
- Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation.International journal of oral science · 2016Trial
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Periodontitis History Shapes the Early Peri-Implant Microbiome Formation: A Metagenomic Analysis.Journal of clinical periodontology · 2025Article
- Data-driven mathematical and visualization approaches for removing rare features for Compositional Data Analysis (CoDA).NAR genomics and bioinformatics · 2024Article
- Effect of mobile app-based oral hygiene instructions on clinical parameters, oral bacterial diversity, and composition of subgingival microbiota in periodontitis patients.Journal of oral microbiology · 2024Article
- Methotrexate and Non-Surgical Periodontal Treatment Change the Oral-Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study.Microorganisms · 2023Article
- Association of Herpesvirus and Periodontitis: A Clinical and Laboratorial Case-Control Study.European journal of dentistry · 2023Article
- Standard operating procedures for the collection, processing, and storage of oral biospecimens at the Korea Oral Biobank Network.Journal of periodontal & implant science · 2023Article
- Subgingival host-microbiome metatranscriptomic changes following scaling and root planing in grade II/III periodontitis.Journal of clinical periodontology · 2023Article
- Effect of Periodontal Interventions on Characteristics of the Periodontal Microbial Profile: A Systematic Review and Meta-Analysis.Microorganisms · 2022Article
- Effect of electronic cigarette and tobacco smoking on the human saliva microbial community.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment.International journal of molecular sciences · 2022Review
- Nonsurgical Periodontal Treatment Options and Their Impact on Subgingival Microbiota.Journal of clinical medicine · 2022Article
- Microbiota in Periodontitis: Advances in the Omic Era.Advances in experimental medicine and biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Periodontitis is a progressive disease of the periodontium with a complex, polymicrobial etiology. Recent Next-Generation Sequencing (NGS) studies of the microbial diversity associated with periodontitis have revealed strong, community-level differences in bacterial assemblages associated with healthy or diseased periodontal sites. In this study, we used NGS approaches to characterize changes in periodontal pocket bacterial diversity after standard periodontal treatment. Despite consistent changes in the abundance of certain taxa in individuals whose condition improved with treatment, post-treatment samples retained the highest similarity to pre-treatment samples from the same individual. Deeper phylogenetic analysis of periodontal pathogen-containing genera Prevotella and Fusobacterium found both unexpected diversity and differential treatment response among species. Our results highlight how understanding interpersonal variability among microbiomes is necessary for determining how polymicrobial diseases respond to treatment and disturbance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.