ArticlePloS one2014
Reaction time and mortality from the major causes of death: the NHANES-III study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cognitive function in childhood and cardiovascular disease risk factors up to 6 decades later: Pooled data from two birth cohort studies.medRxiv : the preprint server for health sciences · 2026Article
- Concurrent Changes in 24-Hour Movement Behaviors and Cognitive Function during Retirement Transition: Longitudinal Compositional Data Analysis.Medicine and science in sports and exercise · 2025Article
- Limited Evidence to Review-Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?NeuroSci · 2025Review
- Combined association of dietary fibre and cognitive function with all-cause and cause-specific mortality in older adults.Annals of medicine · 2023Article
- Development and Validation of Risk Scores for All-Cause Mortality for a Smartphone-Based "General Health Score" App: Prospective Cohort Study Using the UK Biobank.JMIR mHealth and uHealth · 2021Review
- Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.International journal of environmental research and public health · 2020Article
- Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study.Journal of the American Geriatrics Society · 2017Article
- A watershed model of individual differences in fluid intelligence.Neuropsychologia · 2016Article
- Decreased reaction time variability is associated with greater cardiovascular responses to acute stress.Psychophysiology · 2016Article
- Association of Cognitive Function With Cause-Specific Mortality in Middle and Older Age: Follow-up of Participants in the English Longitudinal Study of Ageing.American journal of epidemiology · 2016Article
- The Effect of Neurobehavioral Test Performance on the All-Cause Mortality among US Population.BioMed research international · 2016Article
- Is it Worth the Effort? Novel Insights into Obesity-Associated Alterations in Cost-Benefit Decision-Making.Frontiers in behavioral neuroscience · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveStudies examining the relation of information processing speed, as measured by reaction time, with mortality are scarce. We explored these associations in a representative sample of the US population.
methodsParticipants were 5,134 adults (2,342 men) aged 20-59 years from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-94).
resultsAdjusted for age, sex, and ethnic minority status, a 1 SD slower reaction time was associated with a raised risk of mortality from all-causes (HR = 1.25, 95% CI 1.12, 1.39) and cardiovascular disease (CVD) (HR = 1.36, 95% CI 1.17, 1.58). Having 1 SD more variable reaction time was also associated with greater risk of all-cause (HR = 1.36, 95% CI 1.19, 1.55) and CVD (HR = 1.50, 95% CI 1.33, 1.70) mortality. No associations were observed for cancer mortality. The magnitude of the relationships was comparable in size to established risk factors in this dataset, such as smoking.
interpretationAlongside better-established risk factors, reaction time is associated with increased risk of premature death and cardiovascular disease. It is a candidate risk factor for all-cause and cause-specific mortality.
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