ArticlePloS one2014
Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review.Journal of immunology research · 2015Pooled it
- cnm-positive Streptococcus mutans is associated with IgA nephropathy: a comparative study among kidney diseases.Clinical and experimental nephrology · 2026Article
- Association between Oral Streptococcus Mutans Counts and Proteinuria in Patients with Chronic Kidney Disease: A Pilot Study Using Chlorhexidine.JMA journal · 2026Article
- Relationship between oral microbiota and chronic kidney disease: facts and perspectives.Journal of oral microbiology · 2026Review
- Oral microbiota and urinary system diseases: from mechanistic insights to clinical implications-a comprehensive review.Frontiers in dental medicine · 2026Review
- Article
- cnm-positive Streptococcus mutans, a major pathogen in dental caries, may exacerbate IgA nephropathy via the tonsils.Clinical and experimental nephrology · 2025Article
- Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals.International journal of molecular sciences · 2024Article
- Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.Clinical and experimental nephrology · 2024Article
- Association between gingival bleeding and hematuria as biomarkers of periodontitis and renal disease: a review.Odontology · 2024Review
- Article
- cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy.PloS one · 2023Article
- [Research Progress in the Correlation Between Oral Microbiota and Chronic Kidney Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis.International journal of molecular sciences · 2022Review
- Relationship between IgA Nephropathy andInternational journal of molecular sciences · 2021Article
- Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries.Scientific reports · 2021Article
- Dysbiosis in the Salivary Microbiome Associated with IgA Nephropathy-A Japanese Cohort Study.Microbes and environments · 2021Article
- Potential Roles of Oral Microbiota in the Pathogenesis of Immunoglobin A Nephropathy.Frontiers in cellular and infection microbiology · 2021Article
- Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions.Clinical and experimental nephrology · 2020Article
- Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoglobulin (Ig)A nephropathy (IgAN) is the most common form of primary glomerulonephritis in the world. Some bacteria were reported to be the candidate of the antigen or the pathogenesis of IgAN, but systematic analysis of bacterial flora in tonsil with IgAN has not been reported. Moreover, these bacteria specific to IgAN might be candidate for the indicator which can predict the remission of IgAN treated by the combination of tonsillectomy and steroid pulse. METHODS AND
findingsWe made a comprehensive analysis of tonsil flora in 68 IgAN patients and 28 control patients using Denaturing gradient gel electrophoresis methods. We also analyzed the relationship between several bacteria specific to the IgAN and the prognosis of the IgAN. Treponema sp. were identified in 24% IgAN patients, while in 7% control patients (P = 0.062). Haemophilus segnis were detected in 53% IgAN patients, while in 25% control patients (P = 0.012). Campylobacter rectus were identified in 49% IgAN patients, while in 14% control patients (P = 0.002). Multiple Cox proportional-hazards model revealed that Treponema sp. or Campylobactor rectus are significant for the remission of proteinuria (Hazard ratio 2.35, p = 0.019). There was significant difference in remission rates between IgAN patients with Treponema sp. and those without the bacterium (p = 0.046), and in remission rates between IgAN patients with Campylobacter rectus and those without the bacterium (p = 0.037) by Kaplan-Meier analysis. Those bacteria are well known to be related with the periodontal disease. Periodontal bacteria has known to cause immune reaction and many diseases, and also might cause IgA nephropathy.
conclusionThis insight into IgAN might be useful for diagnosis of the IgAN patients and the decision of treatment of IgAN.
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