ArticleClinical & developmental immunology2013
The role of cytokines in the functional activity of phagocytes in blood and colostrum of diabetic mothers.
Article in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Melatonin Modulates Macrophage Polarization and Immunometabolic Responses in the Colostrum of Obese Mothers.Metabolites · 2026Article
- Resistin as Modulator of Functional Activity of Phagocytes in Colostrum and Blood of Overweight and Obese Mothers.Biomedicines · 2025Article
- Gestational Diabetes Mellitus Alters Cytokine Profiles and Macrophage Polarization in Human Placenta.International journal of molecular sciences · 2025Article
- The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection.Biomolecules · 2024Article
- Serotonin and Interleukin 10 Can Influence the Blood and Urine Viscosity in Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence.International journal of molecular sciences · 2023Article
- Cholinergic Polarization of Human Macrophages.International journal of molecular sciences · 2023Review
- Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition.Frontiers in immunology · 2022Article
- Immunogenic Properties of MVs Containing Structural Hantaviral Proteins: An Original Study.Pharmaceutics · 2022Article
- Effects of Modified Melatonin Release on Human Colostrum Neutrophils to Induce Death in the MCF-7 Cell Line.International journal of cell biology · 2022Article
- Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum.Journal of immunology research · 2019Article
- Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.Parasitology research · 2018Article
- Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers.Journal of immunology research · 2016Article
- Intracellular calcium is a target of modulation of apoptosis in MCF-7 cells in the presence of IgA adsorbed to polyethylene glycol.OncoTargets and therapy · 2016Article
- Changes in the biochemical and immunological components of serum and colostrum of overweight and obese mothers.BMC pregnancy and childbirth · 2015Article
- The effect of IFN-γ and TGF-β in the functional activity of mononuclear cells in the presence of Entamoeba histolytica.Parasites & vectors · 2015Article
- Nanoparticles of barium induce apoptosis in human phagocytes.International journal of nanomedicine · 2015Article
- Effects of Cytokines IFN-γ and TGF-β on the Functional Activity of Blood Mononuclear Cells againstIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune response changes induced by diabetes are a risk factor for infections during pregnancy and may modify the development of the newborn's immune system. The present study analyzed colostrum and maternal and cord blood of diabetic women to determine (1) the levels of the cytokines IFN- γ and TGF- β and (2) phagocytic activity after incubation with cytokines. Methods. Colostrum and maternal and cord blood samples were classified into normoglycemic (N = 20) and diabetic (N = 19) groups. Cytokine levels, superoxide release, rate of phagocytosis, bactericidal activity, and intracellular Ca(2+) release by phagocytes were analyzed in the samples. Irrespective of glycemic status, IFN- γ and TGF- β levels were not changed in colostrum and maternal and cord blood. In maternal blood and colostrum, superoxide release by cytokine-stimulated phagocytes was similar between the groups. Compared to spontaneous release, superoxide release was stimulated by IFN- γ and TGF- β in normoglycemic and diabetic groups. In the diabetic group, cord blood phagocytes incubated with IFN- γ exhibited higher phagocytic activity in response to EPEC, and maternal blood exhibited lower microbicidal activity. These data suggest that diabetes interferes in maternal immunological parameters and that IFN- γ and TGF- β modulate the functional activity of phagocytes in the colostrum, maternal blood, and cord blood of pregnant diabetic women.
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