Evidence map›Paper›PMID 24489562›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2013

HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations.

Cécile Tremblay, Isabelle Hardy, Richard Lalonde, Benoit Trottier, Irina Tsarevsky, Louis-Philippe Vézina, Michel Roger, Mark Wainberg, Jean-Guy Baril

Abstract read
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In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. HIV-1CViruses · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cécile TremblayCentre hospitalier de l'Université de Montréal; ; Laboratoire de santé publique du Québec;
Isabelle HardyCentre hospitalier de l'Université de Montréal; ; HIV Genotyping Program;
Richard LalondeMcGill University Health Centre; ; Advisory Committee on the Clinical Management of Persons Living with HIV;
Benoit TrottierCentre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale l'Actuel;
Irina TsarevskyAdvisory Committee on the Clinical Management of Persons Living with HIV; ; Service de lutte contre les infections transmissibles sexuellement et par le sang, ministère de la Santé et des Services sociaux;
Louis-Philippe VézinaAdvisory Committee on the Clinical Management of Persons Living with HIV; ; Programme national de mentorat sur le VIH-sida;
Michel RogerCentre hospitalier de l'Université de Montréal; ; HIV Genotyping Program;
Mark WainbergMcGill AIDS Centre; ; McGill University, Montreal, Quebec;
Jean-Guy BarilCentre hospitalier de l'Université de Montréal; ; Advisory Committee on the Clinical Management of Persons Living with HIV; ; Clinique médicale du Quartier Latin.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.

Indexed as

CCR5HIVMaravirocTropism

Identifiers

PMID24489562
PMCPMC3905003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.