ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2013
Reduction of central line-associated bloodstream infection rates in a neonatal intensive care unit after implementation of a multidisciplinary evidence-based quality improvement collaborative: A four-year surveillance.
Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 39 citations in OpenAlex.
- Guides, algorithms and other support tools to improve neonatal and pediatric venous access care: A scoping review.Journal of hospital medicine · 2026Article
- Ethical considerations regarding the treatment of extremely preterm infants at the limit of viability: a comprehensive review.European journal of pediatrics · 2025Review
- Advancements in neonatology through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Preventive bundles to reduce catheter-associated bloodstream infections in neonatal intensive care.GMS hygiene and infection control · 2018Article
- Reducing peripherally inserted central catheters in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Bloodstream Infection Incidence of Different Central Venous Catheters in Neonates: A Descriptive Cohort Study.Frontiers in pediatrics · 2017Article
- Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort.BMJ (Clinical research ed.) · 2016Observational
- Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review.World journal of clinical pediatrics · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of central venous catheters has permitted lifesaving treatment for critically ill neonates; however, the attributable mortality rate for central line-associated bloodstream infections (CLABSIs) has been estimated to be between 4% and 20%. In 2006/2007, the authors' neonatal intensive care unit (NICU) had a CLABSI rate that was nearly twofold higher than that reported by other Canadian NICUs.
objectiveTo implement a quality improvement collaborative to reduce the incidence of neonatal CLABSI.
methodsA retrospective observational study was performed to compare CLABSI in neonates admitted to the authors' level III NICU between August 2007 and March 2011. The entire study period was divided into four time periods to evaluate secular trends. A comprehensive catheter-related bloodstream infection prevention initiative was implemented in August 2007. The initiatives included staff education, standardization of skin preparation protocol, introduction of new antiseptic agents, implementation of central catheter insertion and maintenance checklists, reinforcement of the use of maximal sterile barrier precautions, and revision of the central catheter configuration and maintenance protocols.
resultsThe median CLABSI rate of 7.9 per 1000 catheter days at the beginning of the study (period 1 [August 2007 to June 2008]) gradually decreased over the entire study period (P=0.034): period 2 (July 2008 to May 2009), 3.3 per 1000 catheter days; period 3 (June 2009 to April 2010), 2.6 per 1000 catheter days; and period 4 (May 2010 to March 2011), 2.2 per 1000 catheter days.
conclusionA multidisciplinary evidence-based quality improvement collaborative resulted in a significant reduction in the CLABSI rate. Continuous quality improvement measures are required to reduce catheter-related bloodstream infections among low-birth-weight infants.
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