ArticleNeuropsychiatric disease and treatment2014
Pediatric neurofibromatosis 1 and parental stress: a multicenter study.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychosocial implications of rare genetic skin diseases affecting appearance on daily life experiences, emotional state, self-perception and quality of life in adults: a systematic review.Orphanet journal of rare diseases · 2023Pooled it
- Effects on Parental Stress of Early Home-Based CareToy Intervention in Low-Risk Preterm Infants.Neural plasticity · 2019Trial
- Quality of Life and Mental Health Among Families Caring for Children with Medical Complexity: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Parenting stress and health-related quality of life among parents of extremely preterm born early adolescents in England: a cross-sectional study.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Noli Timere: The Role of Reassuring Adults in Dealing with COVID-19 Anxiety in Pediatric Age.Pediatric reports · 2021Review
- Clinical Management of Children and Adolescents with Neurofibromatosis Type 1 Like Phenotypes and Complex Behavioural Manifestations: A Multidisciplinary and Dimensional Approach.Case reports in psychiatry · 2019Article
- Weekend-Based Parent-Group Intervention to Reduce Stress in Parents of Children and Adolescents with Type 1 Diabetes: A Pilot Study.Journal of diabetes research · 2019Article
- 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.American journal of medical genetics. Part A · 2018Article
- Worries and needs of adults and parents of adults with neurofibromatosis type 1.American journal of medical genetics. Part A · 2018Article
- Association Between Parenting Stress and Functional Impairment Among Children Diagnosed with Neurodevelopmental Disorders.Community mental health journal · 2017Article
- Parenting Stress and Emotional/Behavioral Problems in Adolescents with Primary Headache.Frontiers in neurology · 2017Article
- Maternal Stress and Coping Strategies in Developmental Dyslexia: An Italian Multicenter Study.Frontiers in psychiatry · 2017Article
- The Quality of Life in Girls with Rett Syndrome.Mental illness · 2016Article
- Behavioral Phenotype and Autism Spectrum Disorders in Cornelia de Lange Syndrome.Mental illness · 2015Article
- Clinical correlates of parenting stress in children with Tourette syndrome and in typically developing children.The Journal of pediatrics · 2015Article
- Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review.Neuropsychiatric disease and treatment · 2015Article
- Patient and caregiver perspectives on neurodevelopmental and mental health care for RASopathies.Therapeutic advances in rare diseaseArticle
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurofibromatosis 1 (NF1) is a complex and multifaceted neurocutaneous syndrome with many and varied comorbidities. The literature about the prevalence and degree of maternal stress and the impact of NF1 in the parent-child interaction is still scant. The aim of this study was to evaluate the prevalence of maternal stress in a large pediatric sample of individuals affected by NF1.
methodsThirty-seven children (19 boys, 18 girls) of mean age 7.86±2.94 (range 5-11) years affected by typical NF1 and a control group comprising 405 typically developing children (207 boys, 198 girls; mean age 8.54±2.47 years) were included in this study. To assess parental stress, the mothers of all individuals (NF1 and comparisons) filled out the Parenting Stress Index-Short Form test.
resultsThe two study groups were comparable for age (P=0.116), gender (P=0.886), and body mass index adjusted for age (P=0.305). Mothers of children affected by NF1 reported higher mean Parenting Stress Index-Short Form scores on the Parental Distress domain (P<0.001), Difficult Child domain (P<0.001), and Total Stress domain than the mothers of typically developing children (controls) (P<0.001). No significant differences between the two groups were found for the Parent-Child Dysfunctional Interaction domain (P=0.566) or Defensive Responding domain scores (P=0.160).
conclusionNF1 is considered a multisystemic and complex disease, with many still unrecognized features in pediatric patients and in their families. In this light, our findings about the higher levels of maternal stress highlight the importance of considering the environmental aspects of NF1 management in developmental age.
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