Trial reportMediators of inflammation2013
Complement C3c as a biomarker in heart failure.
Trial report in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Complement component 3c and tumor necrosis factor-α systemic assessment after Candida antigen immunotherapy in cutaneous warts.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Trial
- The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications.Signal transduction and targeted therapy · 2025Review
- Exploring molecular characteristics and interactions of blood stasis syndrome in ischemic heart failure by integrated multi-omics.Frontiers in molecular biosciences · 2025Article
- Reward system activation improves recovery from acute myocardial infarction.Nature cardiovascular research · 2024Article
- Charting the Proteoform Landscape of Serum Proteins in Individual Donors by High-Resolution Native Mass Spectrometry.Analytical chemistry · 2022Article
- Alternative C3 Complement System: Lipids and Atherosclerosis.International journal of molecular sciences · 2021Article
- Hemorrhagic shock induces renal complement activation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Novel lncRNA-miRNA-mRNA Competing Endogenous RNA Triple Networks Associated Programmed Cell Death in Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- iTRAQ-based proteomics reveals serum protein changes in hypertensive rats induced by a high-salt diet.EXCLI journal · 2020Article
- Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction.Scientific reports · 2019Article
- Myocardial expression of the anaphylatoxin receptor C3aR is associated with cardiac inflammation and prognosis in patients with non-ischaemic heart failure.ESC heart failure · 2018Article
- Effect of Repeated Freeze-Thaw on Serum Biomarkers Associated with Eye Disease.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study.BMC oral health · 2018Article
- Complement and contact system activation in acute congestive heart failure patients.Clinical and experimental immunology · 2017Article
- Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels.ESC heart failure · 2017Article
- The alternative complement pathway is dysregulated in patients with chronic heart failure.Scientific reports · 2017Article
- Complement C3a predicts outcome in cardiac resynchronization therapy of heart failure.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Observational
- Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode.Journal of clinical laboratory analysis · 2016Observational
- Effects of Chinese medicine shen-fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in a porcine model.Chinese journal of integrative medicine · 2016Article
- Complement Split Products in Amniotic Fluid in Pregnancies Subsequently Developing Early-Onset Preeclampsia.Disease markers · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExperimental data indicates an important role of the innate immune system in cardiac remodeling and heart failure (HF). Complement is a central effector pathway of the innate immune system. Animals lacking parts of the complement system are protected from adverse remodeling. Based on these data, we hypothesized that peripheral complement levels could be a good marker for adverse remodeling and prognosis in patients with HF. METHODS AND
resultsSince complement activation converges on the complement factor C3, we measured serum C3c, a stable C3-conversion product, in 197 patients with stable systolic HF. Subgroups with normal and elevated C3c levels were compared. C3c levels were elevated in 17% of the cohort. Patients with elevated C3c levels exhibited a trend to better survival, slightly higher LVEF, and lower NTpro-BNP values in comparison to patients with normal C3c values. No differences were found regarding NYHA functional class. Significantly more patients with elevated C3c had preexisting diabetes. The prevalence of CAD, arterial hypertension, and atrial fibrillation was not increased in patients with elevated C3c.
conclusionElevated C3c levels are associated with less adverse remodeling and improved survival in patients with stable systolic heart failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.