ArticleAngewandte Chemie (International ed. in English)2014
Fourier transform EPR spectroscopy of trityl radicals for multifunctional assessment of chemical microenvironment.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Synthesis and Characterization of Pyridine-Containing Tetrathiatriarylmethyl (TAM) Stable Radicals for Biomedical Magnetic Resonance Applications.The Journal of organic chemistry · 2026Article
- Electron Spin Resonance Probe Incorporation into Bioinks Permits Longitudinal Oxygen Imaging of Bioprinted Constructs.Molecular imaging and biology · 2024Article
- In Vivo Electron Paramagnetic Resonance Molecular Profiling of Tumor Microenvironment upon Tumor Progression to Malignancy in an Animal Model of Breast Cancer.Molecular imaging and biology · 2024Article
- Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression.Journal of the National Cancer Institute · 2023Article
- Biocompatible Monophosphonated Trityl Spin Probe, HOPE71, for In Vivo Measurement of pOAnalytical chemistry · 2023Article
- Rapid Scan EPR Oxygen Imaging in Photoactivated Resin Used for Stereolithographic 3D Printing.3D printing and additive manufacturing · 2021Article
- Large-scale synthesis of a monophosphonated tetrathiatriarylmethyl spin probe for concurrentRSC advances · 2021Article
- Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- AAngewandte Chemie (International ed. in English) · 2020Article
- Chemical exchange induced Hahn echo modulation in pulsed electron paramagnetic resonance experiment.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.The Analyst · 2020Article
- Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging.Bioorganic & medicinal chemistry letters · 2019Article
- Injectable Oxygen Sensitive Chitosan Complex with High Oxygen Sensitivity and Stability to Oxidoreductants.ACS biomaterials science & engineering · 2019Article
- In Vivo Molecular Electron Paramagnetic Resonance-Based Spectroscopy and Imaging of Tumor Microenvironment and Redox Using Functional Paramagnetic Probes.Antioxidants & redox signaling · 2018Review
- In Vivo Application of Proton-Electron Double-Resonance Imaging.Antioxidants & redox signaling · 2018Review
- In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment.Journal of visualized experiments : JoVE · 2018Article
- Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe.Cell biochemistry and biophysics · 2017Article
- Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment.Analytical chemistry · 2017Review
- Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression.Scientific reports · 2017Article
- Trityl radicals in perfluorocarbon emulsions as stable, sensitive, and biocompatible oximetry probes.Bioorganic & medicinal chemistry letters · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Pulse techniques in electron paramagnetic resonance (EPR) allow for a reduction in measurement times and increase in sensitivity but require the synthesis of paramagnetic probes with long relaxation times. Here it is shown that the recently synthesized phosphonated trityl radical possesses long relaxation times that are sensitive to probe the microenvironment, such as oxygenation and acidity of an aqueous solution. In principle, application of Fourier transform EPR (FT-EPR) spectroscopy makes it possible to acquire the entire EPR spectrum of the trityl probe and assess these microenvironmental parameters within a few microseconds. The performed analysis of the FT-EPR spectra takes into consideration oxygen-, proton-, buffer-, and concentration-induced contributions to the spectral shape, therefore enabling quantitative and discriminative assessment of pH, pO2, and concentrations of the probe and inorganic phosphate.
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Registered trials
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