ReviewCurrent osteoporosis reports2014
Vitamin D deficiency and its role in muscle-bone interactions in the elderly.
Review in Current osteoporosis reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status.Nutrition research (New York, N.Y.) · 2017Pooled it
- Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration.Genomics, proteomics & bioinformatics · 2015Pooled it
- Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT.Nutrition and cancer · 2021Trial
- The effect of vitamin D supplementation on the muscle damage after eccentric exercise in young men: a randomized, control trial.Journal of the International Society of Sports Nutrition · 2020Trial
- Challenges and dilemmas of exercise therapy in the management of osteoporosis: a narrative review.Frontiers in endocrinology · 2026Review
- Vitamin D status and site-specific fracture pattern associations in older adults with fragility fractures: a cross-sectional analysis of 2543 patients.Frontiers in nutrition · 2026Article
- The association between hand grip strength and chronic kidney disease progression: insights from SMP-CKD studies.International urology and nephrology · 2025Observational
- Vitamin D deficiency in hip fracture patients is associated with an increased mortality risk.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Nutritional Challenges in Nursing Homes: Pilot Study on Macronutrient Intake and Status of Vitamins D and B12.Nutrients · 2024Article
- Assessment of selected muscle damage markers and zonulin concentration after maximum-intensity exercise in men with type 1 diabetes treated with a personal insulin pump.Acta diabetologica · 2023Article
- Hand grip strength, vitamin D status, and diets as predictors of bone health in 6-12 years old school children.BMC musculoskeletal disorders · 2023Observational
- Osteomalacia Prevalence, Biochemical Profile, and Histology in Patients with Low-Energy Hip Fractures Over the Age of 45.Calcified tissue international · 2023Article
- Nutritional Support for Liver Diseases.Nutrients · 2023Review
- Article
- Coexistence of Osteomalacia in Osteoporotic Hip Fractures in More Than 50 Years Age Group.Indian journal of orthopaedics · 2021Article
- Proximal muscle strength as a predictor of vitamin D insufficiency in elderly.Turkish journal of physical medicine and rehabilitation · 2021Article
- Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function.Journal of cachexia, sarcopenia and muscle · 2019Article
- Anabolism to Catabolism: Serologic Clues to Nutritional Status in Heart Failure.Current heart failure reports · 2019Review
- Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection.Aging and disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this commentary, we focus on common 'downstream' links of vitamin D between muscle and bone health. Both direct and indirect effects of 1,25 dihydroxyvitamin D (1,25(OH)D) link the mutual age-related decline in muscle function and bone density, independent of physical activity. Changes in calcium absorption associated with vitamin D deficiency affect both muscle and bone mass. The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -α and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Controversial findings on the role of 1,25(OH)D on skeletal muscle may relate to differences in vitamin D receptor expression throughout different stages of muscle cell differentiation. Prolonged vitamin D insufficiency in the elderly is associated with reductions in both bone mineral density and type 2 muscle fibers with the outcomes of skeletal fragility in combination with reduced muscle power, leading to increased risk of falls and fracture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.