ArticleJournal of molecular neuroscience : MN2014
Quercetin and omega 3 ameliorate oxidative stress induced by aluminium chloride in the brain.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Therapeutic Potential of Select Berry Varieties in Mitigating Cognitive Decline via Oxidative Stress and Insulin Resistance in AlClBrain and behavior · 2026Article
- Nutraceuticals: A strategy to mitigate neurotoxicity.Advances in neurotoxicology · 2026Article
- Protective Effect of Boric Acid on Oxidative Damage and Cognitive Function in Aging Modeled Rats.Medeniyet medical journal · 2025Article
- Protective effects of omega-3 against procarbazine-induced brain damage in the cerebellum and CA1 Hippocampus of male rats: a focus on oxidative stress mechanisms.Metabolic brain disease · 2025Article
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- Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies.Advances in neurotoxicology · 2021Article
- Onion (Iranian journal of pharmaceutical research : IJPR · 2021Review
- Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model.Nutrients · 2017Article
- Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications.Environmental science and pollution research international · 2017Article
- Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice.Immunologic research · 2017Article
- Zinc Improves Cognitive and Neuronal Dysfunction During Aluminium-Induced Neurodegeneration.Molecular neurobiology · 2017Article
- Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.Schizophrenia bulletin · 2015Review
- Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney.Saudi journal of biological sciences · 2015Article
- Molecular mechanisms of anti-hyperglycemic effects of Costus speciosus extract in streptozotocin-induced diabetic rats.Saudi medical journal · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to high levels of aluminum (Al) leads to neurodegeneration, which may be mediated through over-generation of free radicals. So, in the present study, we investigated the ability of both quercetin and omega 3 to ameliorate adverse effects of Al on brain antioxidants by monitoring the main brain antioxidant enzymes on molecular and cellular levels. The obtained results indicated that Al induced oxidative stress through induction of free radical production and inhibition of activity and expression of the antioxidant enzymes catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx); and at the same time induced superoxide dismutase (SOD) activity and gene expression. Both quercetin (QE) and omega 3 have the ability to overcome Al-induced oxidative stress, manifested by the significant reduction in free radical concentration and induction of the activity and gene expression of the brain antioxidant enzymes.
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