ArticlePediatric nephrology (Berlin, Germany)2014
Anterior ischemic optic neuropathy in pediatric peritoneal dialysis: risk factors and therapy.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Anterior and posterior ischemic optic neuropathy in a child with focal segmental glomerulosclerosis on hemodialysis.Pediatric nephrology (Berlin, Germany) · 2024Article
- Bioimpedance analysis in children on peritoneal dialysis: to fill or not to fill?Pediatric nephrology (Berlin, Germany) · 2024Article
- Shift from severe hypotension to salt-dependent hypertension in a child with autosomal recessive polycystic kidney disease after bilateral nephrectomies: a case report.BMC nephrology · 2023Article
- Acute bilateral vision loss in a toddler with stage 5 chronic kidney disease: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Early clinical management of autosomal recessive polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Anterior Ischemic Optic Neuropathy in a Child Receiving Chronic Hemodialysis.Case reports in nephrology · 2020Article
- Bilateral Anterior Ischaemic Optic Neuropathy in a Child on Continuous Peritoneal Dialysis: Case report and literature review.Sultan Qaboos University medical journal · 2016Article
- Peritoneal dialysis in infants: never lose sight of-and from-arterial hypotension!Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisArticle
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSudden blindness caused by anterior ischemic optic neuropathy (AION) is a rare complication for patients undergoing peritoneal dialysis (PD). Prognosis is generally poor, with AION commonly resulting in permanent visual loss.
methodsWe first describe four case reports of children with AION during PD treatment. We then review ten additional AION cases reported in the literature and compare these 14 affected patients with a control cohort of 59 non-affected patients in the Vienna PD registry.
resultsSignificant risk factors for AION were identified as median age (4 vs. 27 months; p < 0.001), autosomal recessive polycystic kidney disease (28.6 vs. 3.4%; p = 0.01), anephric status (53.8 vs. 6.8%; p < 0.001) and low to normal blood pressure evidenced by the number of patients having to be treated with antihypertensive medications (14.3 vs. 62.7%; p = 0.01). Severe hypovolemia was reported in 50% of all cases. Outcome was visual loss with optic atrophy in nine patients; five patients had a good visual outcome. The major difference in treatment was a rapid bolus of saline within 12 h after the initial symptoms.
conclusionsYoung age, autosomal recessive polycystic kidney disease, anephric status and hypotension are substantial risk factors for AION. Early hospitalization with vascular refilling within a few hours following onset of blindness leads to improved visual outcome.
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