SynthesisThe Journal of rheumatology2014
Outcome measures used in clinical trials for Behçet syndrome: a systematic review.
Synthesis in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Active Control,Randomized,Double- Blinded Clinical Trial of BD
Development and Preliminary Validation of the Behçet's Disease Overall Damage Index
Inactivity Behavior and Exercise Bariers in Patients With Behçet Disease
Evaluation of Topical Rebamipide Versus Topical Betamethasone for Management of Oral Ulcers in Behcet's Disease: A Randomized Clinical Trial
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Interventions for the management of oral ulcers in Behçet's disease.The Cochrane database of systematic reviews · 2014Pooled it
- Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial.Clinical oral investigations · 2022Trial
- The diagnostic value of ultrasonographic vein wall thickness measurement in patients with Behçet's disease.Journal of rheumatic diseases · 2025Article
- Review
- New and future perspectives in Behçet's syndrome.Archives of rheumatology · 2024Review
- Expression Levels and Clinical Values of miR-195, miR-424, miR-10b, miR-103a-3p, and miR-542-3p in Vasculo-Behçet's Disease.Mediterranean journal of rheumatology · 2024Article
- Reducing the carbon footprint of cataract surgery: co-creating solutions with a departmental Delphi process.Eye (London, England) · 2024Article
- Increased inferior vena cava wall thickness as a sign of extensive venous inflammation in Behçet's Disease.Clinical rheumatology · 2024Article
- Can the mucosal attacks of Behçet's disease be predicted?Archives of dermatological research · 2024Article
- Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study.Frontiers in immunology · 2024Article
- Paediatric Behçet's Disease: A Comprehensive Review with an Emphasis on Monogenic Mimics.Journal of clinical medicine · 2022Review
- Behçet syndrome.Nature reviews. Disease primers · 2021Review
- Ultrasonographic measurement of the vascular wall thickness and intima-media thickness in patients with Behçet's disease with symptoms or signs of vascular involvement: A cross-sectional study.Archives of rheumatology · 2021Article
- Empowering Patients in the Therapeutic Decision-Making Process: A Glance Into Behçet's Syndrome.Frontiers in medicine · 2021Article
- Development and preliminary validation of the Behçet's syndrome Overall Damage Index (BODI).RMD open · 2020Article
- Does illness perception associate with disease symptoms in Behçet's disease?Internal and emergency medicine · 2019Article
- Evaluation of treatment adherence in patients with Behçet's disease: its relation to disease manifestations, patients' beliefs about medications, and quality of life.Clinical rheumatology · 2019Article
- Systemic vasculitis and patient-reported outcomes: how the assessment of patient preferences and perspectives could improve outcomes.Patient related outcome measures · 2019Review
- What are the priorities for improving cataract surgical outcomes in Africa? Results of a Delphi exercise.International ophthalmology · 2018Article
- Behçet syndrome: a contemporary view.Nature reviews. Rheumatology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Behçet syndrome (BS) is a multisystem vasculitis that is most active during young adulthood, causing serious disability and significant impairment in quality of life. Differences in the disease course, severity, and organ involvement between patients, depending on the age at presentation and sex, makes it impossible to determine a single management strategy. The diversity and variability in the outcome measures used in clinical trials in BS makes it difficult to compare the results or inform physicians about the best management strategy for individual patients. There is a large unmet need to determine or develop validated outcome measures for use in clinical trials in BS that are acceptable to researchers and regulatory agencies. We conducted a systematic review to describe the outcomes and outcome measures that have been used in clinical trials in BS. This review revealed the diversity and variability in the outcomes and outcome measures and the lack of standard definitions for most outcomes and rarity of validated outcome tools for disease assessment in BS. This systematic literature review will identify domains and candidate instruments for use in a Delphi exercise, the next step in the development of a core set of outcome measures that are properly validated and widely accepted by the collaboration of researchers from many different regions of the world and from different specialties, including rheumatology, ophthalmology, dermatology, gastroenterology, and neurology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.