ArticleClinical research in cardiology : official journal of the German Cardiac Society2014
Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 20 citations in OpenAlex.
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- Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study.Journal of atherosclerosis and thrombosis · 2020Article
- Association of longitudinal risk profile trajectory clusters with adipose tissue depots measured by magnetic resonance imaging.Scientific reports · 2019Article
- Association between Serum Copeptin and Stroke in Rural Areas of Northern China: A Matched Case-Control Study.Disease markers · 2018Article
- In-stent restenosis after interventional treatment of carotid artery stenoses: a long-term follow-up of a single center cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Article
- Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.Croatian medical journal · 2016Article
- Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes.Medicine · 2016Observational
- Prognostic role of N-terminal pro-brain natriuretic peptide in asymptomatic hypertensive and diabetic patients in primary care: impact of age and gender : Results from the PROBE-HF study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- The value of noncoronary atherosclerosis for identifying coronary artery disease: results of the Leipzig LIFE Heart Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Biomarkers Related to Carotid Intima-Media Thickness and Plaques in Long-Term Survivors of Ischemic Stroke.Translational stroke research · 2015Article
- Low levels of natural IgM antibodies against phosphorylcholine are independently associated with vascular remodeling in patients with coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
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14 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the Gutenberg Health Study, a random sample of the population was scanned with vascular ultrasound for early atherosclerosis. A continuous classical risk marker model (waist circumference, HbA1c, LDL/HDL ratio, pack years and pulse pressure) was compared to a model of modern biomarkers (C-reactive protein, troponin I, N-terminal pro B-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin, and asymmetric dimethylarginine) with regard to the ability of ruling out abnormal intima-media thickness (IMT), respectively, carotid plaques.
methodsData of the first consecutive 5,000 participants (aged 35-74 years; 2,540 men, 2,460 women) were analyzed. IMT was measured at both common carotid arteries using an edge detection system. Plaques were defined as protrusion of ≥1.5 mm in common, internal and external carotid artery.
resultsFor classical risk factors, in comparison to a model of six modern biomarkers, regarding the variable (a) IMT>0.85 mm negative and positive predictive value (NPV and PPV) were 0.98 and 0.16 for both the classical risk factor model and the biomarker model. The second variable (b) presence of plaque could be ruled out with an NPV of 0.84 and identified with a PPV of 0.61 for classical risk factors, and 0.84 and 0.58 for biomarkers, respectively. Values were calculated using logistic regression analysis.
conclusionClassical risk factors allow ruling out pathologic IMT and presence of carotid plaques in a population of primary prevention in a reliable way. Modern biomarkers performed almost equally well but did not provide further information.
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