ArticlePediatric research2014
Effects of preoperative hypoxia on white matter injury associated with cardiopulmonary bypass in a rodent hypoxic and brain slice model.
Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
- Symptomatic newborn coronary fistula repair without cardiopulmonary bypass.JTCVS techniques · 2023Article
- Article
- Impact of Cardiopulmonary Bypass on Neurogenesis and Cortical Maturation.Annals of neurology · 2021Article
- Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain usingNMR in biomedicine · 2021Article
- The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care.Pediatric neurology · 2020Review
- Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease.Journal of the American Heart Association · 2019Article
- EPAS 1, congenital heart disease, and high altitude: disclosures by genetics, bioinformatics, and experimental embryology.Bioscience reports · 2019Article
- White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model.Developmental neuroscience · 2019Article
- Application of a neuroscience research model to study neuroprotection in children with congenital heart disease.The Journal of thoracic and cardiovascular surgery · 2018Article
- Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model.Journal of the American Heart Association · 2017Article
- Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation.Circulation research · 2017Review
- Original Research: Establishment of an early embolus-related cerebral injury model after cardiopulmonary bypass in miniature pigs.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Anomalies of Ventriculoarterial Connections and Immature Brain Development.World journal for pediatric & congenital heart surgery · 2016Review
- Hypoxia diminishes the protective function of white-matter astrocytes in the developing brain.The Journal of thoracic and cardiovascular surgery · 2016Article
- Congenital cardiac anomalies and white matter injury.Trends in neurosciences · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhite matter (WM) injury is common after cardiopulmonary bypass or deep hypothermic circulatory arrest in neonates who have cerebral immaturity secondary to in utero hypoxia. The mechanism remains unknown. We investigated effects of preoperative hypoxia on deep hypothermic circulatory arrest-induced WM injury using a combined experimental paradigm in rodents.
methodsMice were exposed to hypoxia (prehypoxia). Oxygen-glucose deprivation was performed under three temperatures to simulate brain conditions of deep hypothermic circulatory arrest including ischemia-reperfusion/reoxygenation under hypothermia.
resultsWM injury in prenormoxia was identified after 35 °C-oxygen-glucose deprivation. In prehypoxia, injury was displayed in all groups. Among oligodendrocyte stages, the preoligodendrocyte was the most susceptible, while the oligodendrocyte progenitor was resistant to insult. When effects of prehypoxia were assessed, injury of mature oligodendrocytes and oligodendrocyte progenitors in prehypoxia significantly increased as compared with prenormoxia, indicating that mature oligodendrocytes and progenitors that had developed under hypoxia had greater vulnerability. Conversely, damage of oligodendrocyte progenitors in prehypoxia were not identified after 15 °C-oxygen-glucose deprivation, suggesting that susceptible oligodendrocytes exposed to hypoxia are protected by deep hypothermia.
conclusionDevelopmental alterations due to hypoxia result in an increased WM susceptibility to injury. Promoting WM regeneration by oligodendrocyte progenitors after earlier surgery using deep hypothermia is the most promising approach for successful WM development in congenital heart disease patients.
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