CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction).

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

1. De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy.Cell · 2025
   Article
2. Riluzole is associated with reduced risk of heart failure.European journal of neurology · 2025
   Article
3. Eleclazine Suppresses Ventricular Fibrillation in Failing Rabbit Hearts with Ischemia-Reperfusion Injury Undergoing Therapeutic Hypothermia.Pharmacology · 2025
   Article
4. Arrhythmias in Patients With Heart Failure Prescribed Dofetilide or Sotalol.JACC. Advances · 2024
   Article
5. Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.American journal of physiology. Heart and circulatory physiology · 2024
   Article
6. Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling.Journal of biomedical science · 2024
   Article
7. American journal of physiology. Heart and circulatory physiology · 2022
   Article
8. Late sodium current and calcium homeostasis in arrhythmogenesis.Channels (Austin, Tex.) · 2021
   Review
9. Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.Scientific reports · 2021
   Article
10. 18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload.Current medical science · 2020
    Article
11. Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents.Frontiers in pharmacology · 2020
    Review
12. Dynamics of sodium current mediated early afterdepolarizations.Heliyon · 2017
    Article
13. Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes.PloS one · 2016
    Article
14. Targets for therapy in sarcomeric cardiomyopathies.Cardiovascular research · 2015
    Review
15. Rebuttal from Zoltan Papp, Attila Borbely and Walter J. Paulus.The Journal of physiology · 2014
    Article

Corrections and comments

• Commented on by
  Rebuttal from Marc Pourrier, Sarah Williams, Donald McAfee, Luiz Belardinelli and David Fedida.2014

Authors and funding

5 authors at 2 institutions in 2 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as