ArticleActa pharmacologica Sinica2014
Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chinese Han population.
Article in Acta pharmacologica Sinica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Single-Cell Transcriptomics Identifies a Pivotal Role of SPHK1Inflammation · 2026Article
- Aortic dissection: the role of macrophages in disease pathogenesis and their potential as a treatment target.Journal of cardiothoracic surgery · 2026Review
- Gut microbiota-derived butyrate prevents aortic dissection via GPR41.Acta pharmacologica Sinica · 2025Article
- The role of oxidative stress in aortic dissection: a potential therapeutic target.Frontiers in cardiovascular medicine · 2024Review
- Gut Microbiota-Derived Tryptophan Metabolite Indole-3-aldehyde Ameliorates Aortic Dissection.Nutrients · 2023Article
- Low Zinc Alleviates the Progression of Thoracic Aortic Dissection by Inhibiting Inflammation.Nutrients · 2023Article
- Chronic Kidney Disease: Combined Effects of Gene Polymorphisms of Tissue Inhibitors of Metalloproteinase 3, Total Urinary Arsenic, and Blood Lead Concentration.International journal of environmental research and public health · 2023Article
- Serum Oxylipin Profiles Identify Potential Biomarkers in Patients with Acute Aortic Dissection.Metabolites · 2022Article
- The association between lymphocyte-monocyte ratio and postoperative acute kidney injury in patients with acute type A aortic dissection.Journal of cardiothoracic surgery · 2022Article
- Bioinformatics analysis of common key genes and pathways of intracranial, abdominal, and thoracic aneurysms.BMC cardiovascular disorders · 2021Article
- Copy number variations ofTranslational cancer research · 2020Article
- Association of Toll-Like Receptor 4 Gene Polymorphisms with Acute Aortic Dissection in a Chinese Han Population.BioMed research international · 2020Article
- Genetic Polymorphisms ofDisease markers · 2020Article
- Article
- Observational
- Age and cigarette smoking modulate the relationship between pulmonary function and arterial stiffness in heart failure patients.Medicine · 2017Observational
- Color M-mode echocardiography-derived propagation velocity of descending aorta decreases with aging.Therapeutics and clinical risk management · 2017Article
- Sex differences of in-hospital outcome and long-term mortality in patients with Takotsubo cardiomyopathy.Therapeutics and clinical risk management · 2017Article
- Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction.Therapeutics and clinical risk management · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThoracic aortic dissection (TAD) is the most common life-threatening disorder, and a shifted balance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is involved in TAD pathogenesis. The aim of this study was to evaluate the association of 4 single-nucleotide polymorphisms (SNPs) in MMP-9 and TIMP-3 genes with TAD risk in Chinese Han population.
methodsA total of 206 Chinese patients with TAD and 180 controls were included in this study. Four SNPs (rs3918249, rs2274756, rs9609643 and rs8136803) were genotyped using high-throughput MALDI-TOF mass spectrometry. Allele and genotype association analyses were conducted using PLINK.
resultsAll the 4 SNPs resulted in Hardy-Weinberg equilibrium in patients and controls. The G allele frequency for the MMP-9 SNP rs2274756 was significantly higher in female TAD patients than in female controls (P=0.0099). Moreover, after adjusting for traditional cardiovascular risk factors (sex, age, hypertension, dyslipidemia, diabetes and smoking habit), the rs2274756 polymorphism (odds ratio: 0.30; 95% confidence interval: 0.11 to 0.79, P=0.015) resulted in an independent susceptibility factor for TAD in females. No associations were found between the other SNPs and TAD.
conclusionThe results provide strong evidence for an association between MMP-9 SNP rs2274756 and female TAD risk in Chinese Han population.
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