Trial reportLasers in medical science2014
High-intensity versus low-level laser therapy in the treatment of patients with knee osteoarthritis: a randomized controlled trial.
Trial report in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05148416 (Effect of High Intensity Laser in Treatment of Myofascial Trigger Points in Symptomatic Knee Osteoarthritis), which is not on this map. Cited by 105 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of High Intensity Laser in Treatment of Myofascial Trigger Points in Symptomatic Knee Osteoarthritis : A Randomized Single-blinded Controlled Trial
Who cites it
105 citing papers in PubMed, 12 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Comparison of the effectiveness of high-intensity laser therapy versus low-level laser therapy in musculoskeletal disorders: a systematic review and network meta-analysis.Lasers in medical science · 2026Pooled it
- High-intensity versus low-level laser in musculoskeletal disorders.Lasers in medical science · 2024Pooled it
- Efficacy and safety of laser acupuncture on osteoarthritis: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee.The Cochrane database of systematic reviews · 2022Pooled it
- Effects of low-intensity pulsed ultrasound on knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.Clinical rehabilitation · 2022Pooled it
- Is high intensity laser therapy more effective than other physical therapy modalities for treating knee osteoarthritis? A systematic review and network meta-analysis.Frontiers in medicine · 2022Pooled it
- Association of photobiomodulation therapy (PBMT) and exercises programs in pain and functional capacity of patients with knee osteoarthritis (KOA): a systematic review of randomized trials.Lasers in medical science · 2021Pooled it
- Physical Management of Scar Tissue: A Systematic Review and Meta-Analysis.Journal of alternative and complementary medicine (New York, N.Y.) · 2020Pooled it
- Laser photobiomodulation for cartilage defect in animal models of knee osteoarthritis: a systematic review and meta-analysis.Lasers in medical science · 2020Pooled it
- Pooled it
- The dark art of light measurement: accurate radiometry for low-level light therapy.Lasers in medical science · 2016Pooled it
- Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis.Osteoarthritis and cartilage · 2015Pooled it
- Efficacy of high-intensity laser therapy versus ultrasound therapy in patients with knee osteoarthritis: a randomized controlled trial.Lasers in medical science · 2026Trial
- Comparison of the effectiveness of extracorporeal shock wave therapy and high-intensity laser therapy in patients with knee osteoarthritis: a single-blind randomized clinical trial.Clinical rheumatology · 2026Trial
- High-intensity versus low-intensity laser acupuncture in chronic, non-specific low back pain: a double-blinded, randomized controlled trial.Frontiers in medicine · 2026Trial
- Comparison of the effects of high-intensity laser therapy and low-level laser therapy in knee osteoarthritis.Clinical rheumatology · 2025Trial
- Comparative efficacy of high intensity laser therapy (Class IV) and ibuprofen gel phonophoresis in the treatment of knee osteoarthritis among people living in hilly terrain: A randomized controlled study.Lasers in medical science · 2025Trial
- Additional effect of high-intensity laser therapy with conventional physiotherapy related to pain and function in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled, 12-week follow-up study.Lasers in medical science · 2025Trial
- The efficacy of high-intensity laser and short-wave diathermy both combined with exercises in patients with knee osteoarthritis: a randomized comparative study.Lasers in medical science · 2025Trial
- High-intensity laser therapy can improve pain, health status and quality of life in women with fibromyalgia: a single blinded-randomized controlled trial.Lasers in medical science · 2025Trial
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this randomized controlled study was to compare the effects of low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) on pain relief and functional improvement in patients with knee osteoarthritis (KOA). A total of 53 male patients participated in this study, with a mean (SD) age of 54.6 (8.49) years. Patients were randomly assigned into three groups and treated with HILT and exercise (HILT + EX), LLLT and exercise (LLLT + EX), and placebo laser plus exercise (PL + EX) in groups 1, 2, and 3, respectively. The outcomes measured were pain level measured by visual analog scale (VAS) and knee function measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analyses were performed to compare the differences between baseline and posttreatment measurements. The level of statistical significance was set as P < 0.05. The result showed that HILT and LLLT combined with exercise were effective treatment modalities in decreasing the VAS and WOMAC scores after 6 weeks of treatment. HILT combined with exercises was more effective than LLLT combined with exercises, and both treatment modalities were better than exercises alone in the treatment of patients with KOA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.