ArticleProceedings of the National Academy of Sciences of the United States of America1988
Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrating MALDI-MSI-Based Spatial Proteomics and Machine Learning to Predict Chemoradiotherapy Outcomes in Head and Neck Cancer.International journal of molecular sciences · 2025Article
- Multifaceted role of keratins in epithelial cell differentiation and transformation.Journal of biosciences · 2019Review
- Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma.PloS one · 2012Article
- Article
- Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia.Journal of anatomy · 2009Review
- Cytokeratins 8 and 19 in the mouse placental development.The Journal of cell biology · 2000Article
- The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells.The Journal of cell biology · 1997Article
- Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening.Journal of cancer research and clinical oncology · 1997Article
- Implications of intermediate filament protein phosphorylation.Cancer metastasis reviews · 1996Review
- 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor.The Journal of cell biology · 1996Article
- Changes in keratin expression during fetal and postnatal development of intestinal epithelial cells.The Biochemical journal · 1992Article
- Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.The Journal of cell biology · 1991Article
- Molecular biology of keratinocyte differentiation.Environmental health perspectives · 1989Review
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1 author.
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Abstract
The complete amino acid and DNA sequences of the human 40-kDa keratin are reported. The DNA sequence encodes a protein of 44,098 Da, which is unique in that it lacks the terminal non-alpha-helical tail segment found in all other keratins. When the human 40-kDa keratin amino acid sequence is compared to the corresponding bovine keratin, the overall identity is 89%. The coil-forming regions are 89% identical and the head regions are 88% identical. This similarity is also evident in the DNA sequence of the coding region, the 5' upstream sequences, and the 3' noncoding sequences. The high degree of cross-species identity between bovine and human 40-kDa keratins suggests that there is strong evolutionary pressure to conserve the structure of this keratin. This in turn suggests an important and universal role for this intermediate filament subunit in all species.
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