ArticleNature chemical biology2014
Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness.
Article in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Cracking the Code: Reprogramming the Genetic Script in Prokaryotes and Eukaryotes to Harness the Power of Noncanonical Amino Acids.Chemical reviews · 2024Review
- Robust genetic codes enhance protein evolvability.PLoS biology · 2024Article
- Heat adaptation of phage T7 under an extended genetic code.Virus evolution · 2021Article
- The developing toolkit of continuous directed evolution.Nature chemical biology · 2020Review
- Review
- Transcript degradation and codon usage regulate gene expression in a lytic phage.Virus evolution · 2019Article
- Review
- Xenoprotein engineering via synthetic libraries.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Playing with the Molecules of Life.ACS chemical biology · 2018Review
- Evolving Bacterial Fitness with an Expanded Genetic Code.Scientific reports · 2018Article
- Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.Nature chemical biology · 2017Article
- Expanding and reprogramming the genetic code.Nature · 2017Review
- Rewriting the Genetic Code.Annual review of microbiology · 2017Review
- Efforts and Challenges in Engineering the Genetic Code.Life (Basel, Switzerland) · 2017Review
- Future of the Genetic Code.Life (Basel, Switzerland) · 2017Review
- At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.Cold Spring Harbor perspectives in biology · 2016Review
- Selection platforms for directed evolution in synthetic biology.Biochemical Society transactions · 2016Review
- Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life.Life (Basel, Switzerland) · 2016Article
- Addicting diverse bacteria to a noncanonical amino acid.Nature chemical biology · 2016Article
- Overcoming Challenges in Engineering the Genetic Code.Journal of molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Bioengineering advances have made it possible to fundamentally alter the genetic codes of organisms. However, the evolutionary consequences of expanding an organism's genetic code with a noncanonical amino acid are poorly understood. Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.