Trial reportEuropean archives of psychiatry and clinical neuroscience2014
The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients.
Trial report in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Investigating the effects of different exercise protocols on depressive-like behaviors and brain-derived neurotrophic factor (BDNF) in rodents: a systematic review.Experimental brain research · 2026Pooled it
- Disentangling the biological mechanisms underlying the effects of physical exercise in major depressive disorder: a comprehensive systematic review of randomized controlled trials.Psychological medicine · 2025Pooled it
- The impact of N-acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta-analysis.Journal of cellular and molecular medicine · 2024Pooled it
- The effectiveness of multicomponent exercise in older adults with cognitive frailty: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2024Pooled it
- A Mixed Comparisons of Different Intensities and Types of Physical Exercise in Patients With Diseases Related to Oxidative Stress: A Systematic Review and Network Meta-Analysis.Frontiers in physiology · 2021Pooled it
- The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Trial
- Neuroimaging biomarkers of neuroprotection: Impact of voluntary versus enforced exercise in Alzheimer's disease models.Magnetic resonance imaging · 2025Article
- Physical exercise and depression in university students with psychological resilience as mediator and family support as moderator.Scientific reports · 2025Article
- Physical activity moderates the mediating role of depression between experiential avoidance and Internet addiction.Scientific reports · 2025Article
- Diet, Physical Activity and Depression: Does Gastrointestinal Health Help Explain the Relationship Between Lifestyle Factors and Depression?Nutrition bulletin · 2025Article
- The longitudinal relations between physical activity, inflammation, and depression in the Health and Retirement Study.PLOS mental health · 2025Article
- Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Implementation of a Primary Prevention Program for Posttraumatic Stress Disorder in a Cohort of Professional Soldiers (PREPAR): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Effects of activity participation and cognitive levels on depression in middle-aged and older adults with chronic illness: a national cross-sectional study.Frontiers in psychology · 2024Article
- Effects of Home-Based Electrical Stimulation on Plasma Cytokines Profile, Redox Biomarkers, and Metalloproteinases in the Heart Failure with Reduced Ejection Fraction: A Randomized Trial.Journal of cardiovascular development and disease · 2022Article
- Acute Effect of Physical Exercise on Negative Affect in Borderline Personality Disorder: A Pilot Study.Clinical psychology in Europe · 2022Article
- Exercise improves mental health status of young adultsFrontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise can be an effective treatment for depression. Although the efficacy of exercise is well established, little is known concerning the biological changes associated with the antidepressant effects of exercise. A randomized, controlled trial was conducted to evaluate the effects of adding exercise to the usual treatment on the thiobarbituric acid-reactive substances (TBARS) and brain-derived neurotrophic factor (BDNF) serum levels of severely depressed inpatients. Twenty-six participants were randomized to an exercise group (n=15, exercise+treatment as usual) or a control group (n=11, treatment as usual). The participants in the exercise group completed a targeted dose of 16.5 kcal/kg/week of aerobic exercise, three times per week, throughout their hospitalizations. The control group did not exercise during their hospitalizations. The mean hospitalization length was of 21.63 (4.5)×23.82 (5.7) days for exercise and control groups, respectively. The exercise group performed a median of nine sessions. After adjusting for previous tobacco use, a significant group×time interaction was found for TBARS serum levels (p=0.02). A post hoc Bonferroni test revealed differences between the exercise and control groups at discharge. A significant time effect (p<0.001) but no group×time interaction was found (p=0.13) for BDNF serum levels. Adding exercise to the usual treatment of severely depressed inpatients decreases the TBARS serum levels of severely depressed inpatients after 3 weeks. Adding exercise had no additional effects on BDNF serum levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.