ArticleNature neuroscience2014
Cortical activity in the null space: permitting preparation without movement.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 461 papers.
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Who cites it
461 citing papers in PubMed.
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- Cognitive-Motor Duality in Human M1 and Cerebellum.Research square · 2026Article
- Temporal Indexing of Motor Memory.bioRxiv : the preprint server for biology · 2026Article
- Preparatory encoding of intended movement in the human motor cortex and implications for brain-computer interfaces.Current biology : CB · 2026Article
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- Electrical Microstimulation in Macaque Early Visual Cortex Reveals Causal Links to Color Perception.Neuroscience bulletin · 2026Article
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Manifold-constrained plasticity enables stable learning in recurrent neural circuits.PLoS computational biology · 2026Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- Anticipatory organization of neural population dynamics speeds behavioral decisions.bioRxiv : the preprint server for biology · 2026Article
- Learning-related population dynamics in right and left dorsal premotor cortex during typing skill acquisition.bioRxiv : the preprint server for biology · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
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401 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Neural circuits must perform computations and then selectively output the results to other circuits. Yet synapses do not change radically at millisecond timescales. A key question then is: how is communication between neural circuits controlled? In motor control, brain areas directly involved in driving movement are active well before movement begins. Muscle activity is some readout of neural activity, yet it remains largely unchanged during preparation. Here we find that during preparation, while the monkey holds still, changes in motor cortical activity cancel out at the level of these population readouts. Motor cortex can thereby prepare the movement without prematurely causing it. Further, we found evidence that this mechanism also operates in dorsal premotor cortex, largely accounting for how preparatory activity is attenuated in primary motor cortex. Selective use of 'output-null' vs. 'output-potent' patterns of activity may thus help control communication to the muscles and between these brain areas.
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