ArticleBehavioural brain research2014
Acute nicotine delays extinction of contextual fear in mice.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Dorsolateral striatal acetylcholine reorganizes neural ensembles to anticipate threat.bioRxiv : the preprint server for biology · 2025Article
- Abnormal response to chronic social defeat stress and fear extinction in a mouse model ofFrontiers in neuroscience · 2025Article
- Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.Biology of sex differences · 2024Article
- Interstrain differences in adolescent fear conditioning after acute alcohol exposure.Brain research bulletin · 2023Article
- Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment.Behavioural brain research · 2021Article
- Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring.Addiction biology · 2021Article
- Sex differences in fear extinction.Neuroscience and biobehavioral reviews · 2019Review
- Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function.Neuropharmacology · 2018Article
- Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory.Behavioral neuroscience · 2018Article
- Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex.Neuroscience letters · 2018Article
- Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice.Behavioural brain research · 2018Article
- Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery.Brain research bulletin · 2018Article
- Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice.Psychopharmacology · 2018Article
- Tyrosine receptor kinase B receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction.Journal of psychopharmacology (Oxford, England) · 2018Article
- Sex differences in the effects of nicotine on contextual fear extinction.Pharmacology, biochemistry, and behavior · 2018Article
- Differential Effects of Nicotine Exposure on the Hippocampus Across Lifespan.Current neuropharmacology · 2018Review
- Digital Delivery of Meditative Movement Training Improved Health of Cigarette-Smoke-Exposed Subjects.Frontiers in public health · 2018Article
- Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity.Neurobiology of learning and memory · 2017Article
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
- Where There is Smoke There is Fear-Impaired Contextual Inhibition of Conditioned Fear in Smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Smoking is linked to post-traumatic stress disorder (PTSD) which suggests smoking is either a risk factor or an attempt at self-medication. The ability to reduce or extinguish fear-related memories may be altered in patients with PTSD and it is possible that nicotine modulates this. Although there are numerous studies examining the effects of nicotine on acquisition of fear learning, the effects of nicotine on extinction of contextual fear are not well understood. In the present study, we examined the effects of acute nicotine (0.18 mg/kg) on extinction of contextual fear in C57BL/6J mice. Animals were first trained in a background contextual fear conditioning paradigm using a white noise as a conditioned stimulus (CS), which co-terminated with a 2 s 0.57 mA unconditioned foot-shock stimulus (US). Animals were then administered either nicotine or saline and exposed to either the training context or a novel context in order to measure freezing to the context during extinction. Our results demonstrate that nicotine administration during extinction delays extinction of contextual freezing while nicotine did not affect cued freezing or freezing to the novel context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.