ArticleBone2014
Mortality of combined serum phosphorus and parathyroid hormone concentrations and their changes over time in hemodialysis patients.
Article in Bone, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison between paricalcitol and active non-selective vitamin D receptor activator for secondary hyperparathyroidism in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.International urology and nephrology · 2016Pooled it
- Serum Phosphorus Concentration and Coronary Artery Calcification in Subjects without Renal Dysfunction.PloS one · 2016Trial
- Distinct longitudinal trajectories of alkaline phosphatase and parathyroid hormone at dialysis initiation predict mortality in incident hemodialysis patients.BMC nephrology · 2026Article
- Calciprotein particles in cats with naturally occurring chronic kidney disease.Journal of veterinary internal medicine · 2026Article
- Chest X-ray Findings and Prognostic Factors in Survival Analysis in Peritoneal Dialysis and Hemodialysis Patients: A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation.Frontiers in physiology · 2023Review
- Comparative Effectiveness of Dialysis Modality on Laboratory Parameters of Mineral Metabolism.American journal of nephrology · 2022Article
- Higher one-year achievement rate of serum phosphate associated with lower cardiovascular mortality in hemodialysis patients.BMC nephrology · 2021Article
- Secondary hyperparathyroidism and adverse health outcomes in adults with chronic kidney disease.Clinical kidney journal · 2021Article
- Review
- The risk of medically uncontrolled secondary hyperparathyroidism depends on parathyroid hormone levels at haemodialysis initiation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Variations of parathyroid hormone and bone biomarkers are concordant only after a long term follow-up in hemodialyzed patients.Scientific reports · 2017Article
- A decrease in intact parathyroid hormone (iPTH) levels is associated with higher mortality in prevalent hemodialysis patients.PloS one · 2017Observational
- Analysis of the kinetics of the parathyroid hormone, and of associated patient outcomes, in a cohort of haemodialysis patients.BMC nephrology · 2016Article
- Pharmacological Management of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease.Drugs · 2016Review
- Changes in Markers of Mineral and Bone Disorders and Mortality in Incident Hemodialysis Patients.American journal of nephrology · 2016Article
- Article
- Vitamin D and cinacalcet administration pre-transplantation predict hypercalcaemic hyperparathyroidism post-transplantation: a case-control study of 355 deceased-donor renal transplant recipients over 3 years.Transplantation research · 2014Article
- Dietary restrictions in dialysis patients: is there anything left to eat?Seminars in dialysisReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMineral and bone disorder (MBD) is common and associated with mortality in patients with chronic kidney disease (CKD) Given that disarrays in serum phosphorus (P) and parathyroid hormone (PTH) levels and their changes over time are closely interrelated, modeling mortality-predictability of their combinations may help improve CKD patient management.
methodsA historical cohort study was undertaken to evaluate the joint effect of serum P and PTH levels on mortality in 107,299 chronic hemodialysis (HD) patients. Changes in serum P and PTH levels over 6months, in particular discordant changes, were also modeled with mortality.
resultsHD patients were 64±15 (mean±SD)years old and included 45% women, 33% African-American, and 59% diabetic. Compared with serum P level ≥7.0mg/dL and PTH level ≥600pg/mL, adjusted hazard ratio (HR) tended to be lowest in patients with serum P level of 3.5-<5.5mg/dL combined with PTH level of 150-<300pg/mL (HR 0.64, 95% confidence interval 0.61-0.67). A change over time in serum P level towards the 3.5-<5.5mg/dL range from higher or lower ranges was associated with a decreased mortality, whereas only change in PTH level from <150pg/mL to 150-<300pg/mL range was associated with a lower risk of mortality. Upon discordant changes of PTH and P, i.e., decrease in one of the two measures while the other increased, no change in mortality risk was observed.
conclusionIn CKD-MBD management, patent survival is the greatest with controlling both serum P and PTH levels in balance. Tailoring an individualized treatment strategy in CKD-MBD may benefit patients. Further studies are needed.
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