Evidence map›Paper›PMID 24486564›Full record

Trial reportBiological research for nursing2014

Influence of mindfulness-based stress reduction (MBSR) on telomerase activity in women with breast cancer (BC).

Cecile A Lengacher, Richard R Reich, Kevin E Kip, Michelle Barta, Sophia Ramesar, Carly L Paterson, Manolete S Moscoso, Irina Carranza, Pinky H Budhrani, Seung Joon Kim and 7 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological research for nursing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04019301 (Caring for Caregivers With Mind-body Exercise), which is not on this map. Cited by 41 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 6 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04019301 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Caring for Caregivers With Mind-body Exercise

TypeinterventionalSponsorUniversity of HoustonRan2019 to 2022Enrolled47ConditionsCaregiver Distress, Physical Function, Quality of LifeArmsBaduanjin Qigong, Community-based, Baduanjin Qigong, Internet-based
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 168 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Mindfulness-based stress reduction for women diagnosed with breast cancer.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Cecile A LengacherCollege of Nursing, University of South Florida, Tampa, FL, USA clengach@health.usf.edu.
Richard R ReichH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA College of Arts and Sciences, University of South Florida Sarasota-Manatee, Manatee County, FL, USA.
Kevin E KipCollege of Nursing, University of South Florida, Tampa, FL, USA.
Michelle BartaCollege of Nursing, University of South Florida, Tampa, FL, USA.
Sophia RamesarCollege of Nursing, University of South Florida, Tampa, FL, USA.
Carly L PatersonCollege of Nursing, University of South Florida, Tampa, FL, USA.
Manolete S MoscosoCollege of Nursing, University of South Florida, Tampa, FL, USA.
Irina CarranzaCollege of Nursing, University of South Florida, Tampa, FL, USA.
Pinky H BudhraniDana-Farber Cancer Institute and Harvard Medical Center, Boston, MA, USA.
Seung Joon KimDepartment of Internal Medicine, Division of Pulmonology, The Catholic University of Korea, Seoul, Republic of Korea.
Hyun Y ParkH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Paul B JacobsenH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Michael J SchellH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Heather S L JimH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Janice Post-WhiteCollege of Nursing, University of South Florida, Tampa, FL, USA.
Jerrica R FariasCollege of Nursing, University of South Florida, Tampa, FL, USA.
Jong Y ParkH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USCatholic University of Korea · KRDana-Farber Cancer Institute · USUniversity of South Florida Sarasota–Manatee · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA131080NCI NIH HHS R01-CA131080
6 · The paper itself

Abstract

Mindfulness-based stress reduction (MBSR) reduces symptoms of depression, anxiety, and fear of recurrence among breast cancer (BC) survivors. However, the effects of MBSR (BC) on telomere length (TL) and telomerase activity (TA), known markers of cellular aging, psychological stress, and disease risk, are not known. This randomized, wait-listed, controlled study, nested within a larger trial, investigated the effects of MBSR (BC) on TL and TA. BC patients (142) with Stages 0-III cancer who had completed adjuvant treatment with radiation and/or chemotherapy at least 2 weeks prior to enrollment and within 2 years of completion of treatment with lumpectomy and/or mastectomy were randomly assigned to either a 6-week MBSR for BC program or a usual care. Assessments of TA and TL were obtained along with psychological measurements at baseline, 6 weeks, and 12 weeks after completing the MBSR(BC) program. The mean age of 142 participants was 55.3 years; 72% were non-Hispanic White; 78% had Stage I or II cancer; and 36% received both chemotherapy and radiation. In analyses adjusted for baseline TA and psychological status, TA increased steadily over 12 weeks in the MBSR(BC) group (approximately 17%) compared to essentially no increase in the control group (approximately 3%, p < .01). In contrast, no between-group difference was observed for TL (p = .92). These results provide preliminary evidence that MBSR(BC) increases TA in peripheral blood mononuclear cells from BC patients and have implications for understanding how MBSR(BC) may extend cell longevity at the cellular level.

Indexed as

MindfulnessAgedBase SequenceBreast NeoplasmsCombined Modality TherapyDNA PrimersFemaleHumansMiddle AgedPolymerase Chain ReactionPregnancyStress, PsychologicalTelomeraseDNA PrimersTelomerasebreast cancerMBSR(BC)mindfulness based stress reductionstresstelomerase activitytelomere length

Identifiers

PMID24486564
PMCPMC4559344
OpenAlexW1972454857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.