Evidence map›Paper›PMID 24486465›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2014

Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury.

Mahasweta Das, Chunyan Wang, Raminder Bedi, Shyam S Mohapatra, Subhra Mohapatra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Management of Traumatic Brain Injury: From Present to Future.Antioxidants (Basel, Switzerland) · 2020
    Review
  11. Imaging of intranasal drug delivery to the brain.American journal of nuclear medicine and molecular imaging · 2020
    Review
  12. Article
  13. Review
  14. Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.Nanomedicine : nanotechnology, biology, and medicine · 2015
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mahasweta DasUSF Morsani College of Medicine, Nanomedicine Research Center, University of South Florida College of Medicine, Tampa, FL, USA; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Chunyan WangUSF Morsani College of Medicine, Nanomedicine Research Center, University of South Florida College of Medicine, Tampa, FL, USA; Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Raminder BediDepartment of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Shyam S MohapatraUSF Morsani College of Medicine, Nanomedicine Research Center, University of South Florida College of Medicine, Tampa, FL, USA; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA. Electronic address: smohapat@health.usf.edu.
Subhra MohapatraUSF Morsani College of Medicine, Nanomedicine Research Center, University of South Florida College of Medicine, Tampa, FL, USA; Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL, USA. Electronic address: smohapa2@health.usf.edu.
Florida College · USUniversity of South Florida · US

Funding

An Integrated Nano-Cell Delivery Platform of Theranostics for Lung CancersR01CA152005 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI MOHAPATRA, SHYAM S, MOHAPATRA, SUBHRA · 2010 to 2014
$1.4M
NCI NIH HHS R01 CA152005
6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes significant mortality, long term disability and psychological symptoms. Gene therapy is a promising approach for treatment of different pathological conditions. Here we tested chitosan and polyethyleneimine (PEI)-coated magnetic micelles (CP-mag micelles or CPMMs), a potential MRI contrast agent, to deliver a reporter DNA to the brain after mild TBI (mTBI). CPMM-tomato plasmid (ptd) conjugate expressing a red-fluorescent protein (RFP) was administered intranasally immediately after mTBI or sham surgery in male SD rats. Evans blue extravasation following mTBI suggested CPMM-ptd entry into the brain via the compromised blood-brain barrier. Magnetofection increased the concentration of CPMMs in the brain. RFP expression was observed in the brain (cortex and hippocampus), lung and liver 48 h after mTBI. CPMM did not evoke any inflammatory response by themselves and were excreted from the body. These results indicate the possibility of using intranasally administered CPMM as a theranostic vehicle for mTBI. From the clinical editor: In this study, chitosan and PEI-coated magnetic micelles (CPMM) were demonstrated as potentially useful vehicles in traumatic brain injury in a rodent model. Magnetofection increased the concentration of CPMMs in the brain and, after intranasal delivery, CPMM did not evoke any inflammatory response and were excreted from the body.

Indexed as

MagneticsMicellesAnimalsBrain InjuriesCell LineContrast MediaDNAMagnetic Resonance ImagingMaleRatsRats, Sprague-DawleyContrast MediaDNAMicellesBio-distributionBrainDNA deliveryLFPIMagnetic micelleTBITheranostic

Identifiers

PMID24486465
PMCPMC4338919
OpenAlexW2080599571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.