ReviewMutation research. Reviews in mutation research2014
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.
Review in Mutation research. Reviews in mutation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- DsDNA breaks inflicted by cell-free chromatin particles selectively target telomeres.Scientific reports · 2025Article
- Article
- Changes in Telomere Length in Leukocytes and Leukemic Cells after Ultrashort Electron Beam Radiation.International journal of molecular sciences · 2024Article
- Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing.Communications biology · 2024Article
- Telomeres and aging: on and off the planet!Biogerontology · 2024Review
- The dynamics of telomere length in primary and metastatic colorectal cancer lesions.Scientific reports · 2023Article
- A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome.International journal of molecular sciences · 2023Review
- Radiation-induced cardiac dysfunction: Practical implications.Kardiologia polska · 2022Review
- Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Neurodevelopmental Consequences of Pediatric Cancer and Its Treatment: The Role of Sleep.Brain sciences · 2020Review
- Shortened Leukocyte Telomere Length Associates with an Increased Prevalence of Chronic Health Conditions among Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Article
- Identification of potential genes and pathways for response prediction of neoadjuvant chemoradiotherapy in patients with rectal cancer by systemic biological analysis.Oncology letters · 2019Article
- Neurocognitive Outcomes and Interventions in Long-Term Survivors of Childhood Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Emerging targets for radioprotection and radiosensitization in radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Comparison of Individual Radiosensitivity to γ-Rays and Carbon Ions.Frontiers in oncology · 2016Article
- Bone marrow failure and the telomeropathies.Blood · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
It is well established that ionizing radiation induces chromosomal damage, both following direct radiation exposure and via non-targeted (bystander) effects, activating DNA damage repair pathways, of which the proteins are closely linked to telomeric proteins and telomere maintenance. Long-term propagation of this radiation-induced chromosomal damage during cell proliferation results in chromosomal instability. Many studies have shown the link between radiation exposure and radiation-induced changes in oxidative stress and DNA damage repair in both targeted and non-targeted cells. However, the effect of these factors on telomeres, long established as guardians of the genome, still remains to be clarified. In this review, we will focus on what is known about how telomeres are affected by exposure to low- and high-LET ionizing radiation and during proliferation, and will discuss how telomeres may be a key player in the process of radiation-induced carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.