Evidence map›Paper›PMID 24486308›Full record

ArticleEuropean urology2014

What is the most bothersome lower urinary tract symptom? Individual- and population-level perspectives for both men and women.

Arnav Agarwal, Leyla N Eryuzlu, Rufus Cartwright, Kristian Thorlund, Teuvo L J Tammela, Gordon H Guyatt, Anssi Auvinen, Kari A O Tikkinen

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06921746 (Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients), which is not on this map. Cited by 122 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06921746 recruitingnot on this mapstarted 2025, after this paper: background citation

Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients

TypeobservationalSponsorUniversity Hospital OstravaRan2025 to 2027Enrolled80ConditionsOveractive BladderArmsUrine Microbiological and Metabolomic Analysis
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 15 syntheses or guidelines pooled it.

  1. Pooled it
  2. Single-incision sling operations for urinary incontinence in women.The Cochrane database of systematic reviews · 2023
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  8. Association between levator ani avulsion and urinary incontinence in women: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Pooled it
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  17. Lower urinary tract symptoms in men: the TRIUMPH cluster RCT.Health technology assessment (Winchester, England) · 2024
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arnav AgarwalDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Leyla N EryuzluDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Rufus CartwrightDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK; Department of Urogynaecology, St. Mary's Hospital, London, UK.
Kristian ThorlundDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Stanford Prevention Research Center, Stanford University, Stanford, CA, USA.
Teuvo L J TammelaDepartment of Urology and School of Medicine, Tampere University Hospital and University of Tampere, Tampere, Finland.
Gordon H GuyattDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Anssi AuvinenSchool of Public Health, University of Tampere, Tampere, Finland.
Kari A O TikkinenDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. Electronic address: kari.tikkinen@gmail.com.

Funding

Medical Research Council G1100377
6 · The paper itself

Abstract

backgroundNo study has compared the bothersomeness of all lower urinary tract symptoms (LUTS) using a population-based sample of adults. Despite this lack of evidence, investigators have often cited their LUTS of interest as the "most bothersome" or "one of the most bothersome."

objectiveTo compare the population- and individual-level burden of LUTS in men and women. DESIGN, SETTING, AND

participantsIn this population-based cross-sectional study, questionnaires were mailed to 6000 individuals (18-79 yr of age) randomly identified from the Finnish Population Register. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The validated Danish Prostatic Symptom Score questionnaire was used for assessment of bother of 12 different LUTS. The age-standardized prevalence of at least moderate bother was calculated for each symptom (population-level burden). Among symptomatic individuals, the proportion of affected individuals with at least moderate bother was calculated for each symptom (individual-level bother). RESULTS AND LIMITATIONS: A total of 3727 individuals (62.4%) participated (53.7% female). The LUTS with the greatest population-level burden were urgency (7.9% with at least moderate bother), stress urinary incontinence (SUI) (6.5%), nocturia (6.0%), postmicturition dribble (5.8%), and urgency urinary incontinence (UUI) (5.0%). Burden from incontinence symptoms was higher in women than men, and the opposite was true for voiding and postmicturition symptoms. At the individual level, UUI was the most bothersome for both genders. Although the response proportion was high, approximately a third did not participate.

conclusionsBoth men and women with UUI report moderate or major bother more frequently than individuals with other LUTS. At the population level, the most prevalent bothersome symptoms are urgency, SUI, and nocturia. PATIENT SUMMARY: Urinary urgency was the most common troubling symptom in a large population-based study; however, for individuals, urgency incontinence was the most likely to be rated as bothersome.

Indexed as

AdolescentAdultAgedCross-Sectional StudiesFemaleFinlandHumansLower Urinary Tract SymptomsMaleMiddle AgedNocturiaPrevalenceSex FactorsSurveys and QuestionnairesUrinary Bladder, OveractiveUrinary Incontinence, StressAge factorsBothersomenessDefinitionLower urinary tract symptomsOveractive bladderPrevalenceSexUrinary incontinenceUrination disordersVoiding dysfunction

Identifiers

PMID24486308
PMCPMC4018666

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.