ReviewFEBS letters2014
Old cogs, new tricks: a scaffolding role for connexin43 and a junctional role for sodium channels?
Review in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Diversity of cells and signals in the cardiovascular system.The Journal of physiology · 2023Article
- Article
- Localization of NaThe Journal of physiology · 2021Article
- Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling.Scientific reports · 2020Article
- Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs.Nanomaterials (Basel, Switzerland) · 2020Article
- The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target.Progress in biophysics and molecular biology · 2019Review
- Connexins and Pannexins in Vascular Function and Disease.International journal of molecular sciences · 2018Review
- Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc.The Journal of physiology · 2018Article
- Electrophysiological mechanisms of long and short QT syndromes.International journal of cardiology. Heart & vasculature · 2017Review
- Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.International journal of cardiology. Heart & vasculature · 2016Review
- Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies.Frontiers in physiology · 2016Review
- Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies.Frontiers in physiology · 2016Review
- Reactive Oxygen Species, Endoplasmic Reticulum Stress and Mitochondrial Dysfunction: The Link with Cardiac Arrhythmogenesis.Frontiers in physiology · 2016Review
- What Is the Arrhythmic Substrate in Viral Myocarditis? Insights from Clinical and Animal Studies.Frontiers in physiology · 2016Review
- Mechanisms of Electrical Activation and Conduction in the Gastrointestinal System: Lessons from Cardiac Electrophysiology.Frontiers in physiology · 2016Review
- Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions.International journal of cardiology. Heart & vasculature · 2015Review
- Role of connexins and pannexins in cardiovascular physiology.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac conduction is the process by which electrical excitation is communicated from cell to cell within the heart, triggering synchronous contraction of the myocardium. The role of conduction defects in precipitating life-threatening arrhythmias in various disease states has spurred scientific interest in the phenomenon. While the understanding of conduction has evolved greatly over the last century, the process has largely been thought to occur via movement of charge between cells via gap junctions. However, it has long been hypothesized that electrical coupling between cardiac myocytes could also occur ephaptically, without direct transfer of ions between cells. This review will focus on recent insights into cardiac myocyte intercalated disk ultrastructure and their implications for conduction research, particularly the ephaptic coupling hypothesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.