ArticleFEBS letters2014
Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments.
Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Extracting phylogenetic dimensions of coevolution reveals hidden functional signals.Scientific reports · 2022Article
- New Model for Stacking Monomers in Filamentous Actin from Skeletal Muscles ofInternational journal of molecular sciences · 2020Article
- Bioinformatics Analysis of Actin Molecules: Why Quantity Does Not Translate Into Quality?Frontiers in genetics · 2020Article
- Conservation of conformational dynamics across prokaryotic actins.PLoS computational biology · 2019Article
- Archaea and the origin of eukaryotes.Nature reviews. Microbiology · 2017Review
- Evolution of polymer formation within the actin superfamily.Molecular biology of the cell · 2017Review
- Structure of the magnetosome-associated actin-like MamK filament at subnanometer resolution.Protein science : a publication of the Protein Society · 2017Article
- The mother of all actins?eLife · 2016Article
- Article
- On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype.Trends in cell biology · 2016Review
- Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- In search of the primordial actin filament.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Archaeal actin from a hyperthermophile forms a single-stranded filament.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.Nature · 2015Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Polymerising proteins of the actin family are nearly ubiquitous. Crenactins, restricted to Crenarchaea, are more closely related to actin than bacterial MreB. Crenactins occur in gene clusters hinting at an unknown, but conserved function. We solved the crystal structure of crenactin at 3.2 Å resolution. The protein crystallises as a continuous right-handed helix with 8 subunits per complete turn, spanning 419 Å. The structure of crenactin shows several loops that are longer than in actin, but overall, crenactin is closely related to eukaryotic actin, with an RMSD of 1.6 Å. Crenactin filaments imaged by electron microscopy showed polymers with very similar helical parameters.
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